1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

HSP

HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.

HSP 相关产品 (34):

Cat. No. Product Name Effect Purity
  • HY-10211
    17-AAG Inhibitor 98.45%
    17-AAG 是 HSP90 的有效抑制剂,IC50 值为 5 nM;对肿瘤细胞中的 HSP90 亲和力比正常细胞中的高100倍。
  • HY-32735
    Triptolide Inhibitor 99.83%
    Triptolide 是一种热休克因子 (HSF1) 抑制剂,抑制 HSP90-CDC37 结合,且诱导 HSP90 乙酰化,也抑制 MDM2 表达,这种作用具有剂量依赖性,IC50 范围为 47 到 73 nM。
  • HY-10215
    NVP-AUY922 Inhibitor 98.17%
    NVP-AUY922 是一种有效的 HSP90 抑制剂,作用于 HSP90α/β,IC50 值分别为 13 nM/21 nM,对 GRP94 和 TRAP-1 的作用较弱。
  • HY-15205
    Ganetespib Inhibitor 99.56%
    Ganetespib 是一种独特的热休克蛋白 90 (HSP90) 抑制剂,在 OSA 8 细胞中,其IC50 值为 4 nM。
  • HY-15230
    Geldanamycin Inhibitor 99.78%
    Geldanamycin 是一种特异性的干扰素调节因子3 (IRF3) 抑制剂,抑制IRF3磷酸化分子伴侣Hsp90。
  • HY-12024
    Alvespimycin hydrochloride Inhibitor 99.32%
    Alvespimycin hydrochloride 是一种有效的 Hsp90 抑制剂,结合到 Hsp90,EC50 为 62±29 nM。
  • HY-101712
    TRC051384 Activator
    TRC051384是热休克蛋白70 (HSP70) 诱导剂。
  • HY-12622
    HSP70-IN-1 Inhibitor 98.05%
    HSP70-IN-1是一种热休克蛋白 (HSP) 抑制剂; 抑制Kasumi-1细胞的生长的IC50值为2.3 μM。
  • HY-B0779
    Teprenone Activator >98.0%
    Teprenone(Geranylgeranylacetone; GGA)是一广泛用于治疗胃溃疡的药物,新近发现其有抗癌作用,且充当热休克蛋白HSP活化剂。
  • HY-19356
    Rocaglamide Inhibitor 99.40%
    Rocaglamide 有效且选择性地作用于热休克因子,IC50 为 50 nM。
  • HY-10941
    VER-155008 Inhibitor 98.83%
    VER-155008是Hsc70/Hsp70新型小分子抑制剂,对HCT116细胞GI50值为5uM。
  • HY-14463
    AT13387 Inhibitor 99.64%
    AT13387是Hsp90抑制剂,对A375细胞的IC50为18 nM,具有长效的抗肿瘤活性。
  • HY-10210
    Retaspimycin Hydrochloride Inhibitor
    Retaspimycin hydrochloride 是一种有效的 Hsp90 ATPase 活性抑制剂。
  • HY-13469
    Debio 0932 Inhibitor 99.44%
    Debio 0932 ( CUDC-305 ) 是HSP90新颖的抑制剂,在很多细胞癌症中有很强的生物活性和抗增殖能力。(IC50值是220 nmol/L)
  • HY-11038
    PU-H71 98.85%
    PU-H71是Hsp90抑制剂,IC50为50 nM。
  • HY-10212
    BIIB021 Inhibitor 99.62%
    BIIB021 是一种可口服的全合成的 HSP90 抑制剂,Ki 值和 EC50 值分别为 1.7 nM 和 38 nM。
  • HY-15190
    NVP-HSP990 Inhibitor 98.59%
    NVP-HSP990(HSP990)是Hsp90抑制剂,对Hsp90_alpha_的IC50值为13nM,抗癌增殖活性。
  • HY-15098
    Apoptozole Inhibitor 99.57%
    Apoptozole是一个通过阻断ATPase活性的Hsp70抑制剂。
  • HY-100872
    KRIBB11 Inhibitor 99.04%
    KRIBB11 是 HSF 的抑制剂,IC50 值为 1.2 μM。
  • HY-10942
    NVP-BEP800 Inhibitor 99.48%
    NVP-BEP800(VER82576)是新型ATP竞争性口服Hsp90抑制剂,IC50为58nM,对Grp94和Trap-1的IC50分别为4.1 μM 和5.5 μM。