2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Hsp90-IN-40

Hsp90-IN-40 (Compound 15b) 是一种热休克蛋白 90 (Hsp90) C 端抑制剂。Hsp90-IN-40 对 SKBr3 和 MCF-7 乳腺癌细胞具有抗增殖活性 (IC50 分别为 2.57 µM 和 2.43 µM)。Hsp90-IN-40 通过抑制 Hsp90 C 端功能，导致 Hsp90 依赖性蛋白降解，从而抑制癌细胞生长。Hsp90-IN-40 可用于乳腺癌的研究。

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Hsp90-IN-40 Chemical Structure

Hsp90-IN-40 Chemical Structure

CAS No. : 2169278-81-1

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Hsp90-IN-40 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hsp90-IN-40 (Compound 15b) is a heat shock protein 90 (Hsp90) C-terminal inhibitor. Hsp90-IN-40 exhibits antiproliferative activity against SKBr3 and MCF-7 breast cancer cells (IC50 of 2.57 µM and 2.43 µM, respectively). Hsp90-IN-40 inhibits cancer cell growth by inhibiting the Hsp90 C-terminal function, leading to Hsp90-dependent protein degradation. Hsp90-IN-40 can be used in breast cancer research[1].

IC50 & Target

HSP90

 

分子量

528.68

Formula

C33H40N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hsp90-IN-40 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hsp90-IN-402169278-81-1HSPHeat shock proteinsHsp90SKBr3 cellsMCF-7 cellsBreast cancerInhibitorinhibitorinhibit

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