2. Others Metabolic Enzyme/Protease GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Reference Standards Tyrosine Hydroxylase Dopamine Receptor OAT
  4. Hydrastine (Standard)

Hydrastine (Standard)  (Synonyms: 北美黄连碱 (Standard); (-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard))

目录号: HY-B0927R 纯度: ≥98%
产品使用指南 技术支持

Hydrastine (Standard) 是 Hydrastine (HY-B0927) 的分析标准品。本产品用于研究及分析应用。Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) 是一种选择性酪氨酸羟化酶 (TH) 竞争性抑制剂，抑制多巴胺的生物合成 (IC50=20.7 μM，PC12 细胞)。Hydrastine 同时抑制有机阳离子转运体 OCT1 (IC50=6.6 μM)。Hydrastine 可能通过线粒体功能障碍，而非氧化应激损伤，导致神经细胞毒性，并与 L-DOPA 联用可加剧细胞凋亡 (apoptosis)。Hydrastine 可用于研究帕金森病相关多巴胺能神经元损伤。

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Hydrastine (Standard) Chemical Structure

Hydrastine (Standard) Chemical Structure

CAS No. : 118-08-1

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生物活性

Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage.

分子量

383.39

Formula

C21H21NO6
CAS 号
中文名称

北美黄连碱 (Standard)；白毛莨碱 (Standard)；金印草素 (Standard)
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Hydrastine (Standard) 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Hydrastine (Standard)118-08-1(-)-β-Hydrastine (Standard)(1R,9S)-β-Hydrastine (Standard)北美黄连碱 (Standard)白毛莨碱 (Standard)金印草素 (Standard)Reference StandardsTyrosine HydroxylaseDopamine ReceptorOATTyrH, THOrganic anion transporterInhibitorinhibitorinhibit

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