2. Others Apoptosis Metabolic Enzyme/Protease Stem Cell/Wnt Immunology/Inflammation JAK/STAT Signaling
  3. TNF Receptor Interleukin Related Pyruvate Kinase STAT Isotope-Labeled Compounds HIF/HIF Prolyl-Hydroxylase NO Synthase COX
  4. Iminostilbene-d10

Iminostilbene-d10 是 Iminostilbene (HY-N7064) 的氘代物。Iminostilbene 是 carbamazepine 的化学前体。同时 Iminostilbene 也是一种具有口服活性的 PKM2 (丙酮酸激酶 M2 型) 和 COX2 (环氧合酶-2) 抑制剂。Iminostilbene 要通过抑制 PKM2 及其与 HIF-1α 和 STAT3 的互作，降低 COX2 和 iNOS 表达，减少 LPS 诱导的 IL-1β、IL-6、TNF-α 和 MCP-1 的释放，从而抑制巨噬细胞炎症反应并改善心肌缺血再灌注 (MI/R) 损伤。Iminostilbene 有望用于炎症调控、心血管疾病 (如心肌缺血再灌注损伤) 及巨噬细胞介导的免疫相关疾病研究。

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Iminostilbene-d<sub>10</sub> Chemical Structure

Iminostilbene-d10 Chemical Structure

CAS No. : 3044090-39-0

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Iminostilbene-d10 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

生物活性

Iminostilbene-d10 is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases[1][2].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Iminostilbene-d10 相关抗体:
分子量

203.31

Formula

C14HD10N
CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Iminostilbene-d10 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iminostilbene-d103044090-39-0TNF ReceptorInterleukin RelatedPyruvate KinaseSTATIsotope-Labeled CompoundsHIF/HIF Prolyl-HydroxylaseNO SynthaseCOXTumor Necrosis Factor ReceptorTNFRILHypoxia-inducible factorsHIFsHIF-PHNitric oxide synthasesNOSCyclooxygenaseInhibitorinhibitorinhibit

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