2. Others Apoptosis Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease NF-κB MAPK/ERK Pathway Stem Cell/Wnt
  3. Reference Standards Apoptosis PPAR NF-κB p38 MAPK ERK Androgen Receptor
  4. Isosilybin A (Standard)

Isosilybin A (Standard)  (Synonyms: 异水飞蓟宾A (Standard))

目录号: HY-N7043R 纯度: ≥98%
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Isosilybin A (Standard) 是 Isosilybin A (HY-N7043) 的分析标准品。Isosilybin A 是一种可从水飞蓟素中分离得到的 PPARγ 激动剂。Isosilybin A 通过靶向 Akt-NF-κB-AR 轴，激活细胞凋亡 (apoptosis) 的外源性和内源性通路。Isosilybin A 通过抑制 Erk 和 p38 信号通路以及 M1 型巨噬细胞极化，缓解玫瑰痤疮模型的炎症反应，其作用靶点与 RELA 和 VEGFA 相关。Isosilybin A 具有抗前列腺癌 (PCA) 活性[1][2][3]。

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Isosilybin A (Standard) Chemical Structure

Isosilybin A (Standard) Chemical Structure

CAS No. : 142796-21-2

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生物活性

Isosilybin A (Standard) is the analytical standard of Isosilybin A (HY-N7043). Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity[1][2][3].

分子量

482.44

Formula

C25H22O10
CAS 号
中文名称

异水飞蓟宾A (Standard)
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Isosilybin A (Standard) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isosilybin A (Standard)142796-21-2异水飞蓟宾A (Standard)Reference StandardsApoptosisPPARNF-κBp38 MAPKERKAndrogen ReceptorPeroxisome proliferator-activated receptorsNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesPPARγrosacea modelcancerNF-kBErkp38ARInflammationInhibitorinhibitorinhibit

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