2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis Autophagy
  3. HSP Apoptosis Autophagy
  4. JD-02

JD-02 是一种新型 Hsp90 抑制剂。JD-02 能诱导细胞自噬 (autophagy) 和细胞凋亡 (apoptosis)。JD-02 增加活性氧水平 (reactive oxygen species)。

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JD-02 Chemical Structure

JD-02 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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JD-02 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JD-02 is a novel Hsp90 inhibitor. JD-02 can induce autophagy and apoptosis. JD-02 increses the level of reactive oxygen species[1].

体外研究
(In Vitro)

JD-02 (0–2  μM, 24, 48, and 72  h) 抑制 HTC116 和 SW620 细胞的生长[1]。
JD-02 (1  μM, 36 72  h) 诱导 HTC116 和 SW620 细胞 G0/G1 期阻滞[1]。 JD-02 (1  μM, 48  h) 诱导 HTC116 和 SW620 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JD-02 相关抗体:

Cell Viability Assay[1]

Cell Line: HTC116 and SW620 cells
Concentration: 0–2  μM
Incubation Time: 24, 48, and 72  h
Result: Inhibited cell growth.

Apoptosis Analysis[1]

Cell Line: HTC116 and SW620 cells
Concentration: 1  μM
Incubation Time: 48 h.
Result: Induced cell apoptosis.

Cell Cycle Analysis[1]

Cell Line: HTC116 and SW620 cells
Concentration: 1  μM
Incubation Time: 36 h
Result: Induced G0/G1 phase arrest.
体内研究
(In Vivo)

JD-02 (5, 10, and 20 mg/kg; 腹腔注射; 21 天) 在 HCT116 细胞异种移植小鼠模型中抑制肿瘤的发展。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT116 cell xenograft mouse model[1]
Dosage: 5, 10, and 20 mg/kg
Administration: Intravenous injection for 21 days
Result: decreased tumor development by 64.3%.
分子量

424.54

Formula

C23H32N6O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JD-02 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JD-02JD02JD 02HSPApoptosisAutophagyHeat shock proteinscolorectal cancerreactive oxygen speciesautophagyapoptosisInhibitorinhibitorinhibit

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产品名称：
JD-02
目录号：
HY-162365
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