2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. Sirtuin Apoptosis
  4. JGB1741

JGB1741  (Synonyms: ILS-JGB-1741)

目录号: HY-111329 纯度: 99.05%
COA 产品使用指南

摩尔计算器

JGB1741 (ILS-JGB-1741) 是一种有效且特异性的 SIRT1 活性抑制剂，IC50 为 ~15 μM。JGB1741 对 SIRT2 和 SIRT3 具有弱的抑制作用，IC50>100 μM。JGB1741 通过调节 Bax/Bcl2 比率、细胞色素 c 释放和 PARP 裂解来增加乙酰化 p53 水平，导致 p53 介导的细胞凋亡。JGB1741 具有用于乳腺癌研究的潜力。

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JGB1741 Chemical Structure

JGB1741 Chemical Structure

CAS No. : 1256375-38-8

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规格 价格 是否有货 数量
1 mg ￥900
In-stock
5 mg ￥3000
In-stock
10 mg ￥4800
In-stock
25 mg ￥9500
In-stock
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100 mg   询价  

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Customer Review

JGB1741 相关抗体

Top Publications Citing Use of Products

查看 Sirtuin 亚型特异性产品:

查看所有亚型
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC50 of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC50>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research[1].

IC50 & Target[1]

SIRT1

∼15 μM (IC50)

SIRT2

>100 μM (IC50)

SIRT3

>100 μM (IC50)

体外研究
(In Vitro)

JGB1741 (ILS-JGB-1741; 1-10000 nM; 24 h) inhibits MDA-MB 231 cell proliferation[1].
JGB1741 (0.01-1 μM; 24 h) induces apoptosis of MDA-MB 231 cells[1].
JGB1741 (0.01-1 μM; 24 h) shows a cell cycle arrest at G1 phase with more and more cells entering into sub G0/G1 phase[1].
JGB1741 (0.01-1 μM; 24 h) shows an increase in the global acetylation of H3K9, p53 expression and acetylated p53K382 levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JGB1741 相关抗体:

Cell Proliferation Assay[1]

Cell Line: K562, HepG2 and MDA-MB 231 cell lines
Concentration: 1, 10, 50, 100, 500, 1000, 10000 nM
Incubation Time: 24 hours
Result: Inhibited MDA-MB 231 cell proliferation more potently with an IC50 of 0.5 μM than K562 and HepG2 cell proliferation (IC50>1 μM).

Apoptosis Analysis[1]

Cell Line: MDA-MB 231 cells
Concentration: 0.01, 0.1, 0.5, 1 μM
Incubation Time:
Result: Showed an increase in the percent apoptotic cells in a dose-dependent fashion with ∼70% apoptosis at 1 μM concentration.

Cell Cycle Analysis[1]

Cell Line: MDA-MB 231 cells
Concentration: 0.01, 0.1, 0.5, 1 μM
Incubation Time:
Result: Showed a cell cycle arrest at G1 phase with more and more cells entering into sub G0/G1 phase, the apoptotic phase, in a dose-dependent fashion.

Western Blot Analysis[1]

Cell Line: MDA-MB 231 cells
Concentration: 0.01, 0.1, 0.5, 1 μM
Incubation Time:
Result: Caused a dose-dependent increase in the global acetylation of H3K9.
Showed an increase in both p53 expression and acetylated p53K382 levels.
分子量

440.56

Formula

C27H24N2O2S
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 5 mg/mL (11.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2698 mL 11.3492 mL 22.6984 mL
5 mM 0.4540 mL 2.2698 mL 4.5397 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

JGB1741 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2698 mL 11.3492 mL 22.6984 mL 56.7460 mL
5 mM 0.4540 mL 2.2698 mL 4.5397 mL 11.3492 mL
10 mM 0.2270 mL 1.1349 mL 2.2698 mL 5.6746 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JGB17411256375-38-8ILS-JGB-1741JGB 1741JGB-1741SirtuinApoptosisacetylatedp53Bax/Bcl2cytochrome cPARPcleavagebreastMDA-MB231G1phaseG0/G1H3K9p53K382K562HepG2Inhibitorinhibitorinhibit

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目录号：
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