Lawsone methyl ether (Synonyms: 2-Methoxy-1,4-naphthoquinone)

目录号: HY-N7116 纯度: 99.16%: Data Sheet SDS COA 产品使用指南
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Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和 Swertia calycina 中分离出的，具有有效的抗真菌和抗菌活性。

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Lawsone methyl ether Chemical Structure

CAS No. : 2348-82-5

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥110	In-stock
50 mg	￥100	In-stock
100 mg	￥170	In-stock
200 mg		询价
500 mg		询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	16.4 μM Compound: 16	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
HL-60	IC₅₀	7.1 μM Compound: 16	Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
Jurkat	IC₅₀	16.1 μM Compound: 16	Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
LS174T	IC₅₀	33.7 μM Compound: 16	Cytotoxicity against human LS174T cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human LS174T cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
MCF7	IC₅₀	6.1 μM Compound: 16	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
MONO-MAC-6	IC₅₀	4.8 μM Compound: 16	Cytotoxicity against human MONO-MAC-6 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MONO-MAC-6 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
MRC5	IC₅₀	5.2 μM Compound: 13	Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 48 hrs by alamar blue assay Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 48 hrs by alamar blue assay	[PMID: 26638044]
PBMC	IC₅₀	29.8 μM Compound: 16	Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
SMMC-7721	IC₅₀	4.3 μM Compound: 23	Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay	[PMID: 21973054]
SW982	IC₅₀	29.8 μM Compound: 16	Cytotoxicity against human SW982 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human SW982 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
THP-1	IC₅₀	16.6 μM Compound: 16	Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
U-937	IC₅₀	13.9 μM Compound: 16	Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
Vero	CC₅₀	13.02 μM Compound: 13	Cytotoxicity against african green monkey Vero cells after 72 hrs by spectrophotometric analysis Cytotoxicity against african green monkey Vero cells after 72 hrs by spectrophotometric analysis	[PMID: 22795899]

体外研究
(In Vitro)

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 对 Candida 的最低抑菌浓度 (MIC) 和最低杀菌浓度 (MFC) 的值均为 1.25 μg/mL^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

188.18

同用名

2-Methoxy-1,4-naphthoquinone

Formula

C₁₁H₈O₃

CAS 号

2348-82-5

性状

固体

颜色

Light yellow to yellow

中文名称

二氯甲基甲醚

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 50 mg/mL (265.70 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.3141 mL	26.5703 mL	53.1406 mL
5 mM	1.0628 mL	5.3141 mL	10.6281 mL
10 mM	0.5314 mL	2.6570 mL	5.3141 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.16%

选择批次：

Data Sheet (598 KB) SDS (393 KB)

COA (288 KB) LCMS (94 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Sritrairat N, et al. Antifungal activity of lawsone methyl ether in comparison with chlorhexidine. J Oral Pathol Med. 2011 Jan;40(1):90-6. [Content Brief]

Lawsone methyl ether 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.3141 mL	26.5703 mL	53.1406 mL	132.8515 mL
	5 mM	1.0628 mL	5.3141 mL	10.6281 mL	26.5703 mL
	10 mM	0.5314 mL	2.6570 mL	5.3141 mL	13.2852 mL
	15 mM	0.3543 mL	1.7714 mL	3.5427 mL	8.8568 mL
	20 mM	0.2657 mL	1.3285 mL	2.6570 mL	6.6426 mL
	25 mM	0.2126 mL	1.0628 mL	2.1256 mL	5.3141 mL
	30 mM	0.1771 mL	0.8857 mL	1.7714 mL	4.4284 mL
	40 mM	0.1329 mL	0.6643 mL	1.3285 mL	3.3213 mL
	50 mM	0.1063 mL	0.5314 mL	1.0628 mL	2.6570 mL
	60 mM	0.0886 mL	0.4428 mL	0.8857 mL	2.2142 mL
	80 mM	0.0664 mL	0.3321 mL	0.6643 mL	1.6606 mL
	100 mM	0.0531 mL	0.2657 mL	0.5314 mL	1.3285 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lawsone methyl ether2348-82-52-Methoxy-1,4-naphthoquinone二氯甲基甲醚FungalBacterialImpatiensbalsaminaSwertiacalycinaantifungalantibacterialInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Lawsone methyl ether (Synonyms: 2-Methoxy-1,4-naphthoquinone)

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