2. Neuronal Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Membrane Transporter/Ion Channel
  3. Serotonin Transporter Trk Receptor PI3K mTOR P-glycoprotein Akt
  4. Levomilnacipran

Levomilnacipran  (Synonyms: (1S,2R)-Milnacipran; F2695)

目录号: HY-14794A
产品使用指南 技术支持

Levomilnacipran ((1S,2R)-Milnacipran) 是 Milnacipran (HY-B0168) 的对映异构体，也是能透过血脑屏障的 P-gp 强底物。Levomilnacipran 是 5-羟色胺和去甲肾上腺素再摄取抑制剂，对人去甲肾上腺素转运体 (NET) 和 5-羟色胺转运体 (SERT) 的 IC50 分别为 10.5 nM 和 19.0 nM，Ki 分别为 92.2 nM 和 1.2 nM。Levomilnacipran hydrochloride 具有抗抑郁与抗焦虑活性。Levomilnacipran 可用于抑郁症的研究。

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Levomilnacipran Chemical Structure

Levomilnacipran Chemical Structure

CAS No. : 96847-54-0

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Levomilnacipran 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Levomilnacipran ((1S,2R)-Milnacipran) is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression[1][2][3][4].

体内研究
(In Vivo)

Levomilnacipran (30 mg/kg; 腹腔注射: 10 天) 在 LPS (HY-D1056) 诱导的抑郁大鼠模型中具有抗抑郁活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats aged 9 weeks old (200-220 g) treated LPS (HY-D1056)[3]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 10 days
Result: Significantly ameliorated depression-like behaviors, including increasing sucrose preference in the SPT, reducing immobility time and increasing swimming time in the FST, and increasing the time spent in the central area in the OFT.
Improved neuronal synaptic deficits and morphological changes in the hippocampus, upregulated the expression of synaptic-related proteins PSD-95 and Syn, activated the BDNF/TrkB mediated PI3K/Akt/mTOR signaling pathway, and suppressed neuroinflammation by regulating the balance of pro- and anti-inflammatory cytokines in the hippocampus.
Clinical Trial
分子量

246.35

Formula

C15H22N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Levomilnacipran 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levomilnacipran96847-54-0(1S,2R)-Milnacipran F2695F2695F 2695F-2695Serotonin TransporterTrk ReceptorPI3KmTORP-glycoproteinAkt5-HTTSERTSLC6A4Tropomyosin related kinase receptor Phosphoinositide 3-kinaseMammalian target of RapamycinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243PKBProtein kinase Bdepressed modelsInhibitorinhibitorinhibit

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