2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. MC0704

MC0704 是一种 STAT3 抑制剂，IC50 值为 2.13 μM。MC0704 诱导细胞凋亡和细胞周期阻滞。MC0704 在小鼠乳腺癌模型中显示出抗肿瘤活性。MC0704 可用于转移性三阴性乳腺癌 (mTNBC) 的研究。

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MC0704 Chemical Structure

MC0704 Chemical Structure

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MC0704 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MC0704 is a STAT3 inhibitor with an IC50 value of 2.13 μM. MC0704 induces cell apoptosis and cell cycle arrest. MC0704 shows antitumor activity in mouse breast cancer models. MC0704 can be used for the research of metastatic triple-negative breast cancer (mTNBC)[1].

体外研究
(In Vitro)

MC0704 (0-50 μM；72 h) 对 HEK-293，肺上皮细胞 (MRC-5)，MDA-MB 231，MDA-MB-231 耐紫杉醇 (MDA-MB-231-PTR) 和 MDA-MB-231 耐多西紫杉醇 (MDA-MB-231-DTR) 细胞具有细胞毒性，IC50 值分别为 3.11，33.25，2.98，3.24 和 2.87 μM[1]。
MC0704 (0，0.4，2，10 和 50 μM；24 h) 抑制 STAT3 活性，IC50 值为 2.13 μM[1]。
MC0704 (5 μM；24 h) 抑制 STAT3 的激活[1]。
MC0704 (0，2.5，5 和 10 μM；36-48 h) 增加 MDA-MB-231-DTR 细胞在 G2/M 期的细胞周期阻滞，诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MC0704 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HEK-293 and MRC-5 cell lines
Concentration: 0-50 μM
Incubation Time: 72 hours
Result: Showed cytotoxicity to HEK-293 and MRC-5 cells.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 TNBC cell line
Concentration: 5 μM
Incubation Time: 24 hour
Result: Inhibited the expression of p-STAT3.
体内研究
(In Vivo)

MC0704 (10 mg/kg，腹腔注射，每日 1 次，12 天) 抑制 MDA-MB-231-DTR 细胞移植小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c-nu mice with MDA-MB-231-DTR cells transplant[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg, once daily for 12 days
Result: Significantly inhibited tumor growth without overt toxicity, and reversed the mesenchymal marker vimentin and epithelial marker E-cadherin expression changes.
分子量

537.41

Formula

C29H21BrN4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MC0704 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC0704MC 0704MC-0704STATβ-carbolineapoptosiscell cycle arrestantitumormTNBCInhibitorinhibitorinhibit

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目录号：
HY-148923
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