2. Academic Validation
  3. TACE inhibition: a new approach to treating inflammation

TACE inhibition: a new approach to treating inflammation

  • Expert Opin Investig Drugs. 2002 Jul;11(7):1003-6. doi: 10.1517/13543784.11.7.1003.
Sheila A Doggrell 1
Affiliations

Affiliation

  • 1 Department of Physiology and Pharmacology, School of Biomedical Sciences, The University of Queensland, QLD 4072, Australia. s_doggrell@yahoo.com
PMID: 12084010 DOI: 10.1517/13543784.11.7.1003
Abstract

Clinical trials showing the benefits of reducing the effects of TNF- alpha in rheumatoid arthritis have highlighted the key role of the cytokine TNF- alpha in this inflammatory condition. A new approach to reducing the effects of TNF- alpha is to decrease its synthesis by inhibiting TNF- alpha converting Enzyme with GW3333. In rat models of arthritis, GW3333 has some beneficial effects. Further longer-term studies of GW3333 in animal models are required to determine whether its benefit is maintained. TACE inhibition may represent a new approach to treating inflammation.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z