1. Metabolic Enzyme/Protease
  2. MMP


MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP 相关产品 (28):

Cat. No. Product Name Effect Purity
  • HY-N0565B
    Doxycycline hyclate Inhibitor 98.42%
    Doxycycline hyclate 是一种四环素抗生素,广谱的金属蛋白酶 (MMP) 抑制剂。
  • HY-15768
    GM6001 Inhibitor 98.23%
    GM6001 是一种广谱的基质金属蛋白酶 (MMP) 抑制剂,能够抑制 MMP-1/2/3/7/8/9/12/14/26 的活性,Ki 值分别为 0.4 nM,0.5 nM,27 nM,3.7 nM,0.1 nM,0.2 nM,3.6 nM,13.4 nM,0.36 nM。
  • HY-12270
    T-5224 Inhibitor 98.41%
    T-5224 是一种有效的 c-Fos/activator protein (AP)-1 抑制剂,同时抑制 MMP 的活性,对 MMP-3 和 MMP-13 的IC50 值均为 10 nM。
  • HY-12354
    SB-3CT Inhibitor 99.32%
    SB-3CT 是一种有效的选择性基质金属蛋白酶 (MMP)-2 和 -9 抑制剂。
  • HY-13564
    Batimastat Inhibitor
    Batimastat 是一种有效的广谱 MMP 抑制剂,作用于 MMP-1MMP-2MMP-9MMP-7MMP-3IC50 分别为 3,4,4,6 和 20 nM。
  • HY-19956
    GI254023X Inhibitor 99.67%
    GI254023X 是一种有效的 MMP9ADAM10 抑制剂, IC50s 分别为 2.5 和 5.3 nM。
  • HY-N0131
    Stigmasterol Inhibitor >98.0%
    Stigmasterol 是一种植物性甾醇,不仅具有降低胆固醇的活性,并且在风湿性疾病的治疗中被评价为抗硬化因子。
  • HY-103482
    JNJ0966 Inhibitor 98.01%
    JNJ0966 是一种高选择性 MMP-9 酶原抑制剂,其 IC50 值为 440 nM。
  • HY-12169
    Marimastat Inhibitor
    Marimastat 是一种广谱的 MMPs 抑制剂,作用于 MMP-9,MMP-1,MMP-2,MMP-14 和 MMP-7,IC50 值分别为 3,5,6,9 和 13 nM。
  • HY-16657
    TAPI-1 Inhibitor 99.89%
  • HY-N0431
    Astragaloside IV Inhibitor 99.15%
    Astragaloside IV 是从黄芪中分到的皂苷类物质,能够抑制 ERK1/2JNK 的激活,在乳腺癌细胞 MDA-MB-231 中,能够下调 (MMP)-2,(MMP)-9 的信号通路。
  • HY-100211
    TAPI-2 Inhibitor
    TAPI-2 是基质金属蛋白酶(MMP),肿瘤坏死因子α转换酶(TACE)和解联蛋白和金属蛋白酶(ADAM)的广谱抑制剂, 对MMP的IC50值为20±10 μM。
  • HY-10398
    CTS-1027 Inhibitor 98.72%
    CTS-1027 是一种有效的 MMP 抑制剂,能够作用于 MMP2MMP13IC50 值分别为 0.3 nM 和 0.5 nM。
  • HY-B0099
    Edaravone Inhibitor 99.90%
    Edaravone 是一种新颖的,有效的自由基清除剂,能够抑制大鼠与 MMP-9 有关的脑出血。
  • HY-100359
    CL-82198 Inhibitor 98.03%
  • HY-15827
    NSC 405020 Inhibitor 99.01%
  • HY-N2117
    Isoginkgetin Inhibitor 99.06%
    Isoginkgetin是MMP9的抑制剂,也是Pre-mRNA Splicing的抑制剂。
  • HY-N0035
    Arctigenin Inhibitor 98.18%
  • HY-101671
    S-methyl-KE-298 >98.0%
    S-methyl-KE-298 是 KE-298 的一种活性代谢物。KE-298 抑制类风湿关节炎 (RA) 滑膜细胞的基质金属蛋白酶 (MMP-1) 产生。
  • HY-N0785
    Ginkgolide C Activator
    Ginkgolide C 是从银杏叶中分离到的黄酮类物质,具有多种生物功能,可以减少血小板聚集,改善阿尔兹海默症等。