1. Metabolic Enzyme/Protease
  2. MMP

MMP

MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP 相关产品 (30):

Cat. No. Product Name Effect Purity
  • HY-N0565B
    Doxycycline hyclate Inhibitor 98.42%
    Doxycycline hyclate 是一种四环素抗生素,广谱的金属蛋白酶 (MMP) 抑制剂。
  • HY-15768
    GM6001 Inhibitor 98.23%
    GM6001 是一种广谱的基质金属蛋白酶 (MMP) 抑制剂,能够抑制 MMP-1/2/3/7/8/9/12/14/26 的活性,Ki 值分别为 0.4 nM,0.5 nM,27 nM,3.7 nM,0.1 nM,0.2 nM,3.6 nM,13.4 nM,0.36 nM。
  • HY-12270
    T-5224 Inhibitor 98.77%
    T-5224 是一种有效的 c-Fos/activator protein (AP)-1 抑制剂,同时抑制 MMP 的活性,对 MMP-3 和 MMP-13 的IC50 值均为 10 nM。
  • HY-13564
    Batimastat Inhibitor
    Batimastat 是一种有效的广谱 MMP 抑制剂,作用于 MMP-1MMP-2MMP-9MMP-7MMP-3IC50 分别为 3,4,4,6 和 20 nM。
  • HY-12354
    SB-3CT Inhibitor 99.32%
    SB-3CT 是一种有效的选择性基质金属蛋白酶 (MMP-2) 和 MMP-9 抑制剂。
  • HY-103482
    JNJ0966 Inhibitor 98.01%
    JNJ0966 是一种高选择性 MMP-9 酶原抑制剂,其 IC50 值为 440 nM。
  • HY-106992
    S 3304 Inhibitor
    S-3304 是一个新型的基质金属蛋白酶 (MMP) 抑制剂, 且对 MMP-2MMP-9 有特异的抑制活性。
  • HY-12169
    Marimastat Inhibitor
    Marimastat 是一种广谱的 MMPs 抑制剂,作用于 MMP-9,MMP-1,MMP-2,MMP-14 和 MMP-7,IC50 值分别为 3,5,6,9 和 13 nM。
  • HY-N0431
    Astragaloside IV Inhibitor 99.15%
    Astragaloside IV 是从黄芪中分到的皂苷类物质,能够抑制 ERK1/2JNK 的激活,在乳腺癌细胞 MDA-MB-231 中,能够下调 (MMP)-2,(MMP)-9 的信号通路。
  • HY-10398
    CTS-1027 Inhibitor 98.72%
    CTS-1027 是一种有效的 MMP 抑制剂,能够作用于 MMP2MMP13IC50 值分别为 0.3 nM 和 0.5 nM。
  • HY-16657
    TAPI-1 Inhibitor 99.89%
    TAPI-1是特异的TACE(TNF-α转换酶)抑制剂。
  • HY-100211
    TAPI-2 Inhibitor
    TAPI-2 是基质金属蛋白酶(MMP),肿瘤坏死因子α转换酶(TACE)和解联蛋白和金属蛋白酶(ADAM)的广谱抑制剂, 对MMP的IC50值为20±10 μM。
  • HY-19956
    GI254023X Inhibitor 99.67%
    GI254023X 是一种有效的 MMP9ADAM10 抑制剂, IC50s 分别为 2.5 和 5.3 nM。
  • HY-B0099
    Edaravone Inhibitor 99.90%
    Edaravone 是一种新颖的,有效的自由基清除剂,能够抑制大鼠与 MMP-9 有关的脑出血。
  • HY-15827
    NSC 405020 Inhibitor 99.01%
    NSC-405020是MT1-MMP抑制剂,能特异地靶向MT1-MMP的PEX结构域,不会抑制MT1-MMP和MMP-2的催化活性。
  • HY-N2117
    Isoginkgetin Inhibitor 99.06%
    Isoginkgetin是MMP9的抑制剂,也是Pre-mRNA Splicing的抑制剂。
  • HY-100359
    CL-82198 Inhibitor 98.03%
    CL-82198是一个选择性的MMP-13抑制剂
  • HY-N0035
    Arctigenin Inhibitor 98.46%
    Arctigenin是存在于一些菊科植物中的木酚素,有抗病毒和抗癌活性。
  • HY-13648
    Incyclinide Inhibitor 98.26%
    Incyclinide (CMT-3, COL-3) 是一种基质金属蛋白酶 (MMP) 抑制剂,诱导细胞外基质降解,抑制血管生成,肿瘤生长和侵袭以及转移。
  • HY-B2162
    Chondroitin sulfate
    Chondroitin sulfate是五种糖胺聚糖之一,已被广泛用于治疗骨关节炎。 Chondroitin sulfate减少炎症介质和凋亡过程,并能够减少炎性细胞因子,iNOSMMPs 产生。
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