2. Neuronal Signaling Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt Cell Cycle/DNA Damage Apoptosis
  3. Trk Receptor Anaplastic lymphoma kinase (ALK) c-Kit EGFR Pim Casein Kinase Checkpoint Kinase (Chk) CDK Apoptosis
  4. Multi-kinase-IN-6

Multi-kinase-IN-6 (compound 10e) 是一种多激酶抑制剂，对 TrkA、ALK2、c-KIT、EGFR、PIM1、CK2α、CHK1 和 CDK2 显示出良好的酶抑制活性。Multi-kinase-IN-6 显示出针对 MCF7、HCT116 和 EKVX 的抗增殖活性，IC50 值分别为 3.36 μM、1.40 μM 和 3.49 μM。Multi-kinase-IN-6 在 MCF7 和 HCT116 细胞中显示细胞周期阻滞在 G1/S 期和 G1 期，具有良好的凋亡 (apoptosis) 效果。

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Multi-kinase-IN-6 Chemical Structure

Multi-kinase-IN-6 Chemical Structure

CAS No. : 3009081-73-3

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Multi-kinase-IN-6 相关抗体

Top Publications Citing Use of Products

查看 Trk Receptor 亚型特异性产品:

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TrkA TrkB TrkC Trk

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Casein Kinase 亚型特异性产品:

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CK1 CK2

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

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Chk1 Chk2

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect[1].

IC50 & Target[1]

TrkA

0.33 μM (IC50)

CDK2

0.71 μM (IC50)

CK2

0.09 μM (IC50)

PIM1

0.42 μM (IC50)

Chk1

0.15 μM (IC50)

EGFR

0.1 μM (IC50)

c-KIT

0.05 μM (IC50)

ALK2

0.03 μM (IC50)

RET

0.53 μM (IC50)

FLT3

0.34 μM (IC50)

ROS1

0.75 μM (IC50)

分子量

321.33

Formula

C17H15N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-kinase-IN-6 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-63009081-73-3Trk ReceptorAnaplastic lymphoma kinase (ALK)c-KitEGFRPimCasein KinaseCheckpoint Kinase (Chk)CDKApoptosisTropomyosin related kinase receptor Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246SCFRCD117Epidermal growth factor receptorErbB-1HER1Pim kinasesCyclin dependent kinaseTrkAALK2c-KITPIM1CK2αCHK1and CDK2Inhibitorinhibitorinhibit

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目录号：
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