2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. NBD-125

NBD-125 (B-12) 是berberine 的类似物，是 RXRα 的激动剂，其在KM12C 细胞中的 IC50 值为31.10 μM。

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NBD-125 Chemical Structure

NBD-125 Chemical Structure

CAS No. : 2367641-24-3

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NBD-125 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].

体外研究
(In Vitro)

NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth[1].
NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NBD-125 相关抗体:

Western Blot Analysis[1]

Cell Line: Km12c, HCT116 and SW620 cell lines.
Concentration: 0-50 μM, 0-60, 0-80 μM.
Incubation Time: 15 h.
Result: Downregulated c-Myc, Cdc42 protein levels.
分子量

327.80

Formula

C19H18ClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NBD-125 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NBD-1252367641-24-3NBD125NBD 125RAR/RXRRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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