Nimbin  (Synonyms: 宁宾)

Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections^[1][2][3][4].

Nimbin (400 μM；0-120 小时) 在肝素诱导的 tau 聚集实验中可抑制 hTau40wt 蛋白的 β- 折叠形成并降低疏水性^[1]。
Nimbin（50 nM-50 μM；24 小时）在 HEK293T 细胞中无细胞毒性，并可挽救 tau 聚集体诱导的细胞死亡^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nimbin 在转基因 tau 病小鼠模型中可减少脑内 tau 聚集并改善认知行为^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

540.60

C₃₀H₃₆O₉

5945-86-8

固体

White to off-white

宁宾

Room temperature in continental US; may vary elsewhere.

• [1]. Nalini V Gorantla, et al. Neem Derivatives Inhibits Tau Aggregation. J Alzheimers Dis Rep. 2019 Jun 14;3(1):169-178.  [Content Brief]

  [2]. P Lavanya, et al. Computational Analysis Reveal Inhibitory Action of Nimbin Against Dengue Viral Envelope Protein. Virusdisease. 2015 Dec;26(4):243-54.  [Content Brief]

  [3]. Li-Juan Yang, et al. Host-guest System of Nimbin and Beta-Cyclodextrin or Its Derivatives: Preparation, Characterization, Inclusion Mode, and Solubilization. J Agric Food Chem. 2010 Aug 11;58(15):8545-52.  [Content Brief]

  [4]. Sidhu O P, et al. Variability in triterpenoids (nimbin and salanin) composition of neem among different provenances of India[J]. Industrial Crops and Products, 2004, 19(1): 69-75.