2. Cell Cycle/DNA Damage Autophagy Anti-infection
  3. Topoisomerase Autophagy Bacterial Antibiotic
  4. Pirarubicin

Pirarubicin  (Synonyms: 吡柔比星; THP)

目录号: HY-13725 纯度: 99.14%
COA 产品使用指南 技术支持

Pirarubicin (THP) 是一种蒽环类抗生素，为拓扑异构酶 II (topoisomerase II) 的抑制剂，可用于各种癌症尤其是实体瘤的研究。

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Pirarubicin

Pirarubicin Chemical Structure

CAS No. : 72496-41-4

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规格 价格 是否有货 数量
5 mg ￥343
In-stock
10 mg ￥523
In-stock
25 mg ￥1176
In-stock
50 mg ￥1999
In-stock
100 mg ￥3713
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Pirarubicin:

Pirarubicin 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pirarubicin is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.

IC50 & Target[1]

Topoisomerase II

 

体外研究
(In Vitro)

Pirarubicin 是一种拓扑异构酶 II 抑制剂[1]。
Pirarubicin对 M5076 和 Ehrlich 细胞有抑制活性，IC50 值分别为 0.366 和 0.078 μM。Pirarubicin 对 M5076 细胞的细胞毒性低于对 Ehrlich 细胞的细胞毒性，这是因为 M5076 细胞中拓扑异构酶 II 的表达比 Ehrlich 细胞中低得多[2]。
Pirarubicin (2.5、5、10 μg/mL) 以剂量依赖性方式显著诱导膀胱癌 (T24、EJ、5637、J82 和 UM-UC-3) 细胞的自噬。此外，Pirarubicin (5 μg/mL) 通过抑制膀胱癌细胞中的 mTOR/p70S6K/4E-BP1 诱导细胞凋亡，并且通过抑制自噬增强这种作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pirarubicin 相关抗体:
体内研究
(In Vivo)

在急性心脏毒性大鼠中，与对照组相比，Pirarubicin (18 mg/kg，静脉注射) 显著升高血清 BNP、CK-MB、CTnT、LDH 和 MDA 水平。在急性心脏毒性模型中，Pirarubicin 还可降低心率、R 波电压和延长 QT 间期[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

627.64

Formula

C32H37NO12
CAS 号
性状

固体

颜色

Pink to red

中文名称

吡柔比星；吡喃阿霉素；吡柔吡星
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (15.93 mM; 超声助溶 (<80°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5933 mL 7.9664 mL 15.9327 mL
5 mM 0.3187 mL 1.5933 mL 3.1865 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.61%

COA (298 KB) HNMR (209 KB) LCMS (314 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[3]

MTS is used to analyze cell survival. Briefly, cells are plated in 96-well plates in triplicate at 2 × 103 cells per well and cultured in growth medium. Then cells are treated with pirarubicin at different concentrations (2.5 μg/mL, 5 μg/mL, 10 μg/mL) for 24 h. MTS reagent (5 mg/mL) is added and incubated at 37°C for 4 h. The absorbance is monitored at 490 nm using a microplate reader[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4]

An acute cardiac toxicity model is established by a single dose of 18 mg/kg pirarubicin through the caudal vein injection. Thirty-six rats are randomized equally to six groups: normal control, cardiac injury (THP) model, dexrazoxane (180 mg/kg), low-dose rutin (25 mg/kg), middle-dose rutin (50 mg/kg), and high-dose rutin (100 mg/kg). Rats in the rutin-treated group are administered different doses of rutin and CMC-Na for 7 days by gavage and a single dose of 18 mg/kg pirarubicin through caudal vein injection. Rats in the dexrazoxane-treated group receive sodium carboxymethylcellulose (CMC-Na) by gavage for six days. 40 mg/kg dexrazoxane is then administered to rats by intraperitoneal injection and 18 mg/kg pirarubicin is administered by caudal vein injection on day 7. Rats in the THP model group receive CMC-Na by gavage for seven days, followed by pirarubicin 18 mg/kg through the caudal vein injection on day 7. Rats in the normal control group receive CMC-Na by gavage for seven days, followed by saline through caudal vein injection on day 7[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Pirarubicin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5933 mL 7.9663 mL 15.9327 mL 39.8317 mL
5 mM 0.3187 mL 1.5933 mL 3.1865 mL 7.9663 mL
10 mM 0.1593 mL 0.7966 mL 1.5933 mL 3.9832 mL
15 mM 0.1062 mL 0.5311 mL 1.0622 mL 2.6554 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pirarubicin72496-41-4THP吡柔比星吡喃阿霉素吡柔吡星TopoisomeraseAutophagyBacterialAntibioticInhibitorinhibitorinhibit

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