REV 5901 hydrochloride 

REV 5901 hydrochloride is a competitive and orally active antagonist of leukotriene receptor, with a K_i of 0.7 μM. REV 5901 hydrochloride is also a 5-lipoxygenase inhibitor. REV 5901 hydrochloride can be used for the research of asthma in which leukotriene release be involved. REV 5901 hydrochloride can be used for the study of colon carcinoma^[1][2][3].

REV 5901 (24 小时) hydrochloride 可抑制 CT26CL25 细胞活力，IC₅₀ 为 30 μM^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

在豚鼠中，REV 5901 (10-30 mg/kg，静脉注射) hydrochloride 显著抑制白三烯 D4 (2.5 μg/kg，静脉注射) 引起的支气管收缩，以气道阻力 (RL) 和动态肺顺应性 (Cdyn) 的变化来衡量₂。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

371.90

C₂₂H₂₆ClNO₂

92532-23-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Inwegen RGV, et, al. REV 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile. J Pharmacol Exp Ther. 1987 Apr;241(1):117-24.  [Content Brief]

  [2]. Anderson G, et, al. Effects of REV 5901, a 5-lipoxygenase inhibitor and leukotriene antagonist, on pulmonary responses to platelet activating factor in the guinea-pig. Br J Pharmacol. 1988 Aug;94(4):1115-22.  [Content Brief]

  [3]. Paskaš S, et al. Carborane-Based Analog of Rev-5901 Attenuates Growth of Colon Carcinoma In Vivo. Molecules. 2022 Jul 14;27(14):4503.  [Content Brief]