1. Metabolic Enzyme/Protease
  2. 5-Lipoxygenase

5-Lipoxygenase

5-Lipoxygenase (5-LOX or 5-LO) is an enzyme that in humans is encoded by the ALOX5 gene. 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. 5-LO catalyzes oxidation of AA at the 5-position to yield 5-HpETE. 5-LO then converts 5-HpETE to leukotriene A4. Recently, oxidized lipid products of 5-LO have been measured in membranes of neutrophils in the form of esterified-5-HETE phospholipids. These novel products have biological activities including inhibition of neutrophil extracellular traps. 5-LO is a target for pharmaceutical intervention in CAD. Some people with variant alleles for 5-LO are at elevated risk for CAD. 5-LO is expressed in brain cells and may participate in neuropathologic processes.

5-Lipoxygenase 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-13419
    U-73122 Inhibitor >98.0%
    U-73122 是磷脂酶C (phospholipase C),磷脂酶A2 (phospholipase A2) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 的有效抑制剂。
  • HY-14164
    Zileuton Inhibitor 99.84%
    Zileuton 是一种有效的,选择性的 5-lipoxygenase 抑制剂,具有抗炎的作用。
  • HY-12341
    ML355 Inhibitor 98.17%
    ML355是一高效、选择性12-LOX抑制剂,IC50值为0.34uM,对其他脂氧化酶和环氧化酶有很好的选择性,具有较好的药物动力学特征。
  • HY-14164A
    Zileuton sodium Inhibitor
    Zileuton sodium 是一种有效的,选择性的 5-lipoxygenase 抑制剂,具有抗炎的作用。
  • HY-101579
    LY 178002 Antagonist
    LY 178002 是一种有效的 cyclooxygenase5-lipoxygenasephospholipase A2 和人多形核白细胞产生的 LTB4 的拮抗剂,对 5-lipoxygenase 的 IC50 值为 0.6 μM。
  • HY-101587
    PGS-IN-1 Inhibitor
    PGS-IN-1是有效的前列腺素合成酶 (prostaglandin synthetase) 抑制剂,IC50 值为0.28 μM;也可抑制5-脂肪氧合酶 (5-lipoxygenase) 的活性,IC50 值为 1.05 μM。
  • HY-U00022
    RWJ 63556 Inhibitor
    RWJ 63556 是一种可口服的 COX-2 selective/5-lipoxygenase 抑制剂,具有抗炎活性。
  • HY-U00024
    Enazadrem Inhibitor
    Enazadrem 是有效的 5-脂氧合酶 (5-lipoxygenase) 抑制剂,具有抗炎功效。
  • HY-19212
    S-2474 Inhibitor
    S-2474 是 COX-2 and 5-lipoxygenase 的抑制剂,为一种非甾体抗炎药。
  • HY-A0060
    Malotilate Inhibitor
    Malotilate可作用于肝细胞,促进其RNA合成,激活核糖体,提高蛋白质合成能力,从而激活肝功能并抑制肝纤维化,还能抑制肝内4-羟基脯氨酸量的增加。