2. GPCR/G Protein Apoptosis MAPK/ERK Pathway
  3. Apoptosis Ras
  4. SHOC2–RAS interaction-IN-1

SHOC2-RAS interaction-IN-1 (compound 6) 是一种靶向 SHOC2 与 RAS 蛋白相互作用的非共价竞争性抑制剂。SHOC2-RAS interaction-IN-1 对 NRASQ61R 的 IC50 为 0.048 μM，KD 为 0.065 μM。SHOC2-RAS interaction-IN-1 可抑制 SMP 磷酸酶复合体活性，导致 CRAFS259 磷酸化水平升高，进而阻断 MAPK 信号通路 (如降低 pMEK、pERK 水平)，诱导肿瘤细胞周期阻滞和凋亡 (apoptosis)。SHOC2-RAS interaction-IN-1 可用于 NRASQ61R 突变的黑色素瘤、结直肠癌等恶性肿瘤的靶向研究。

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SHOC2–RAS interaction-IN-1 Chemical Structure

SHOC2–RAS interaction-IN-1 Chemical Structure

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SHOC2–RAS interaction-IN-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SHOC2-RAS interaction-IN-1 (compound 6) is a non-covalent competitive inhibitor targeting the interaction between SHOC2 and RAS proteins. SHOC2-RAS interaction-IN-1 has an IC50 of 0.048 μM and a KD of 0.065 μM for NRASQ61R. SHOC2-RAS interaction-IN-1 can inhibit the activity of the SMP phosphatase complex, leading to increased CRAFS259 phosphorylation levels, thereby blocking the MAPK signaling pathway (such as reducing the levels of pMEK and pERK), inducing tumor cell cycle arrest and apoptosis. SHOC2-RAS interaction-IN-1 can be used for targeted research on malignant tumors such as melanoma and colorectal cancer with NRASQ61R mutations[1].

分子量

494.28

Formula

C20H19IN2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SHOC2–RAS interaction-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHOC2–RAS interaction-IN-1ApoptosisRasInhibitorinhibitorinhibit

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