2. Signaling Pathways
  3. GPCR/G Protein
    MAPK/ERK Pathway
  4. Ras
  5. Ras Inhibitors

Ras Inhibitors

K-Ras

H-Ras

N-Ras

Ras

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Ras Inhibitors & Antagonists
Product Name K-Ras H-Ras N-Ras Ras Purity
Sotorasib
KRAS(G12C)
      99.94%
MRTX1133
KRas G12D, Kd: 0.2 pM
      99.42%
Adagrasib
KRas G12C
      99.93%
BI-2852
KRAS(G12C), IC50: 450 nM
KRAS(G12C), Kd: 750 nM
      99.57%
BI-3406
KRAS-SOS1, IC50: 6 nM
      99.95%
RMC-6236
KRas G12D
      99.88%
Divarasib
K-Ras(G12C), IC50: <0.01 μM
      99.46%
BAY-293
KRAS-SOS1, IC50: 21 nM
     
RMC-6291
KRAS(G12C)
      99.65%
MRTX0902
KRAS-SOS1, IC50: 46 nM
      99.45%
LC-2
KRAS(G12C), DC50: 0.25-0.76 μM
     
Opnurasib
KRas G12C
      98.94%
ARS-1620
KRAS(G12C)
      99.62%
MRTX-1257
KRAS(G12C)
      99.14%
Sotorasib racemate
KRas G12C
      98.99%
Pan KRas-IN-1
KRas G12D, IC50: 9 nM
KRas G12S, IC50: 11 nM
KRas G12C, IC50: 6 nM
KRas Q61H, IC50: 12 mM
KRas G12V, IC50: 29 mM
K-Ras WT, IC50: 32 nM
      98.47%
PROTAC K-Ras Degrader-1
KRAS(G12C)
      98.05%
RMC-9805
KRAS(G12D)
      99.73%
RM-018
KRAS (G12C)
KRAS (G12C/Y96D)
      98.03%
BI-2493
K-Ras WT
      99.70%
ARS-853
KRAS(G12C), IC50: 2.5 μM
      98.39%
Garsorasib
KRas G12C
      99.11%
MRTX-EX185 formic
KRas G12D, IC50: 90 nM
     
MCP110      
Ras
99.82%
KRAS inhibitor-3
K-Ras WT, EC50: 0.28 μM
KRAS(G12C), EC50: 0.63 μM
KRas G12D, EC50: 0.37 μM
KRas Q61H, EC50: 0.74 μM
      99.65%
ARS-1323-alkyne
KRAS(G12C)
      99.59%
ASP2453
KRas G12C, IC50: 40 nM
      98.04%
KRAS G12D inhibitor 14
KRas G12D, Kd: 33 nM
      99.39%
SAH-SOS1A TFA
KRas G12C, EC50: 140 nM
KRas G12D, EC50: 109 nM
KRas G12V, EC50: 154 nM
KRas G12S, EC50: 155 nM
KRas Q61H, EC50: 175 nM
K-Ras WT, EC50: 106 nM
      99.16%
XRP44X      
Ras, IC50: 10 nM
98.42%
Kobe0065  
H-Ras
    98.01%
AZD4625
KRAS(G12C)
      99.52%
KRpep-2d
K-RAS
     
SOS1-IN-15
SOS1, IC50: 5 nM
      99.51%
BI-0474
KRAS-SOS1, IC50: 7.0 nM
      99.83%
RAS/RAS-RAF-IN-1      
Ras
98.41%
Setidegrasib
KRAS(G12D)
      99.65%
KRAS G12C inhibitor 14
KRas G12C, IC50: 18 nM
      98.07%
ARS-1630
KRAS(G12C)
      98.10%
KRAS G12C inhibitor 15
KRas G12C, IC50: 5 nM
      99.55%
KRAS inhibitor-10
KRas G12C
      99.86%
ARS-1323
KRas G12C
      99.14%
Spiclomazine
KRAS(G12C)
      99.95%
KRAS G12C inhibitor 28
KRas G12C, IC50: 57 nM
      99.94%
DCC-3116
KRas G12C
     
KRpep-2d TFA
K-RAS
      98.11%
Kras4B G12D-IN-1
KRas G12D
      98.01%
Atrovastatin-PEG3-FITC
KRAS-PDEδ
      98.17%
KRas G12C inhibitor 1
KRas G12C
     
CFL-137
KRAS(G12C)
      99.84%
K-Ras G12C-IN-2
KRas G12C
      99.21%
KRAS inhibitor-7
KRAS(G12C)
     
KRAS inhibitor-6
KRAS(G12C)
     
KRAS inhibitor-8
KRAS(G12C)
     
KRAS G12C inhibitor 32
KRAS (G12C)
     
KRAS G12D inhibitor 3
KRas G12D, IC50: <500 nM
     
KRAS G12C inhibitor 27
KRas G12C
     
KRAS inhibitor-14
KRas G12C, IC50: 0.249 μM
     
KRAS G12C inhibitor 18
KRas G12C
     
KRAS G12C inhibitor 17
KRas G12C, IC50: 5 nM
     
KRAS inhibitor-20
KRAS(G12C), IC50: <10 nM ([1])
     
KRAS G12C inhibitor 16
KRas G12C, IC50: 97 nM
     
ASP6918
KRas G12C, IC50: 0.028 μM
     
KRAS inhibitor-16
KRas G12C, IC50: 0.457 μM
     
KRAS G12C inhibitor 13
KRas G12C
     
G12Si-1
KRas G12S
     
SOS1-IN-8
SOS1-G12D, IC50: 11.6 nM
SOS1-G12V, IC50: 40.7 nM
     
TH-Z827
KRAS(G12D), IC50: 2.4 μM
     
KRAS G12C inhibitor 43
KRas G12C
     
CFL-120
KRAS(G12C)
      ≥98.0%
KRAS G12C inhibitor 61
K-Ras WT
     
KRAS G12C inhibitor 53
KRAS(G12C)
     
SOS1-IN-9
KRAS G12C-SOS1, IC50: 116.5 nM
     
KRAS inhibitor-13
KRas G12C, IC50: 0.883 μM
     
KRAS G12C inhibitor 44
KRas G12C
     
KRAS inhibitor-17
KRas G12C, IC50: 3.37 μM
     
KRAS G12C inhibitor 45
KRas G12C
     
KRAS inhibitor-11
K-RAS
     
TH-Z835
KRAS(G12D), IC50: 1.6 μM
     
KRAS G12C inhibitor 55
KRAS(G12C)
     
KRAS G12D inhibitor 3 TFA
KRas G12D, IC50: <500 nM
     
MRTX849 ethoxypropanoic acid
KRas G12C
     
KRAS G12D inhibitor 16
KRas G12D, IC50: 0.7 nM
     
SOS1-IN-7
SOS1-G12D, IC50: 20 nM
SOS1-G12V, IC50: 67 nM
     
SAH-SOS1A
KRas G12C, EC50: 140 nM
KRas G12D, EC50: 109 nM
KRas G12V, EC50: 154 nM
KRas G12S, EC50: 155 nM
KRas Q61H, EC50: 175 nM
K-Ras WT, EC50: 106 nM
     
KRAS G12C inhibitor 59
KRas G12C
     
KRAS G12C inhibitor 52
KRAS(G12C)
     
KRAS inhibitor-12
KRas G12C, IC50: 0.537 μM
     
SOS1-IN-10
KRAS G12C-SOS1, IC50: 13 nM
     
MRTX849 acid
KRas G12C
      99.84%
KRAS inhibitor-15
KRas G12C, IC50: 0.954 μM
     
KRAS G12C inhibitor 47
KRas G12C, IC50: 0.172 μM
     
pan-KRAS-IN-13
KRas G12D, IC50: 2.75 nM
KRas G12V, IC50: 2.89 nM
     
KRAS G12C inhibitor 57
KRAS(G12C), IC50: 0.21 μM (KRAS G12C/SOS1 binding assay)
     
KRAS G12C inhibitor 51
KRAS(G12C)
     
KRAS G12C inhibitor 26
KRas G12C
     
KRAS G12C inhibitor 46
KRas G12C
     
pan-KRAS-IN-3
K-Ras WT
     
(4S)-PROTAC SOS1 degrader-1
K-RAS
     
KRAS G12C inhibitor 48
KRas G12C, IC50: 639.91 nM
     
KRAS G12D inhibitor 7
KRas G12D
     
K-Ras(G12C) inhibitor 6
K-Ras(G12C)
     
Sotorasib-d7
KRAS(G12C)
     
KRAS G12C inhibitor 23
KRas G12C
     
ZG1077
KRas G12C
     
PROTAC SOS1 degrader-3
SOS1
     
KRAS G12C inhibitor 50
KRAS(G12C), IC50: 46.7 nM
     
KRAS inhibitor-18
KRas G12C, IC50: 4.74 μM
     
SOS1-IN-4
KRAS-C12C/SOS1, IC50: 56 nM
     
K20
KRAS(G12C), IC50: 1.16 μM
     
SOS1-IN-6
SOS1-G12D, IC50: 14.9 nM
SOS1-G12V, IC50: 73.3 nM
     
KRAS G12D inhibitor 20
KRas G12D
     
Anticancer agent 207    
NRAS rG4, Kd: 2.31 μM
 
Spiclomazine hydrochloride
K-RAS
     
KRAS G12C inhibitor 25
KRas G12C
     
KRAS G12C inhibitor 54
KRAS(G12C)
     
KRAS G12C inhibitor 62
KRas G12C
     
KRAS inhibitor-23
K-RAS
     
6H05
K-Ras(G12C)
     
KRAS G12C inhibitor 5
KRas G12C
     
KRas G12C inhibitor 2
KRas G12C
     
KRas G12C inhibitor 4
KRas G12C
     
KRas G12C inhibitor 3
KRas G12C
     
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