2. Others Autophagy Apoptosis NF-κB PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt
  3. Reference Standards Autophagy Apoptosis NF-κB PI3K Akt MEK ERK
  4. Sophocarpine (Standard)

Sophocarpine (Standard)  (Synonyms: 槐果碱 (Standard))

目录号: HY-N0103R 纯度: ≥98%
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Sophocarpine (Standard) 是 Sophocarpine (HY-N0103) 的分析标准品。本产品用于研究及分析应用。Sophocarpine 是一种 PTEN 激活剂及 PI3K/Akt、MEK/ERK、NF-κB 信号通路抑制剂。Sophocarpine 上调 PTEN 表达抑制 PI3K/Akt 磷酸化，阻滞肿瘤细胞周期并诱导凋亡 (apoptosis)。Sophocarpine 抑制 MEK/ERK 磷酸化及 VEGF 分泌，减少肿瘤细胞迁移。Sophocarpine 还可抑制 NF-κB 活化及 p38、JNK 磷酸化，降低 iNOS、COX-2 等炎症因子表达，同时激活 Nrf2/HO-1 通路减轻氧化应激。Sophocarpine 具有抗肿瘤、抗炎、抗氧化及抗凋亡作用，可用于胶质母细胞瘤、结直肠癌等癌症及炎症相关疾病、Doxorubicin (HY-15142A) (DOX) 诱导心脏损伤等领域的研究。

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Sophocarpine (Standard) Chemical Structure

Sophocarpine (Standard) Chemical Structure

CAS No. : 6483-15-4

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生物活性

Sophocarpine (Standard) is the analytical standard of Sophocarpine (HY-N0103). This product is intended for research and analytical applications. Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage.

分子量

246.35

同用名

槐果碱 (Standard)

Formula

C15H22N2O
CAS 号
中文名称

槐果碱 (Standard)
结构分类
初始来源
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Sophocarpine (Standard) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sophocarpine (Standard)6483-15-4槐果碱 (Standard)Reference StandardsAutophagyApoptosisNF-κBPI3KAktMEKERKNuclear factor-κBNuclear factor-kappaBPhosphoinositide 3-kinasePKBProtein kinase BMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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