2. Anti-infection
  3. Bacterial Antibiotic
  4. SPR741

SPR741  (Synonyms: NAB741)

目录号: HY-P1649 纯度: 99.08%
COA 产品使用指南 技术支持

SPR741 (NAB741) 是衍生自多粘菌素 B 的阳离子肽，是一种增效剂分子。SPR741 可提高革兰氏阴性细菌外膜的通透性，用于严重的革兰氏阴性细菌感染的研究。SPR741 抑制具有多重耐药性的革兰氏阴性细菌。当与抗生素结合使用时，SPR741 具有扩展抗生素活性谱的能力。

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SPR741 Chemical Structure

SPR741 Chemical Structure

CAS No. : 1179330-52-9

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规格 价格 是否有货 数量
1 mg ￥700
In-stock
5 mg ￥1500
In-stock
10 mg ￥2500
In-stock
25 mg ￥4500
In-stock
50 mg 现货 询价
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of SPR741:

SPR741 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741[1][2].

体外研究
(In Vitro)

SPR741 potentiates antibiotics that are substrates of the AcrAB-TolC efflux pump in E. coli, effectively circumventing the contribution of this pump to intrinsic antibiotic resistance. The intrinsic resistance of E. coli to certain antibiotics that is mediated by both the outer membrane and the AcrAB-TolC efflux system can be overcome, or circumvented, by combining the antibiotic with SPR741 but that potentiation of intrinsic resistance due primarily to efflux may be limited[1].
SPR741 lacks significant antibacterial activity as a stand-alone agent but interacts with the outer membrane of Gram-negative bacteria to increase permeability and thereby improve the accumulation of coadministered antibiotics inside the pathogen[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SPR741 相关抗体:
体内研究
(In Vivo)

SPR741 has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus sensitizing them to hydrophobic antibiotics. SPR741 has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. In multiday rodent and nonhuman primate studies, polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

992.13

Formula

C44H73N13O13
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (100.79 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0079 mL 5.0397 mL 10.0793 mL
5 mM 0.2016 mL 1.0079 mL 2.0159 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SPR741 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0079 mL 5.0397 mL 10.0793 mL 25.1983 mL
5 mM 0.2016 mL 1.0079 mL 2.0159 mL 5.0397 mL
10 mM 0.1008 mL 0.5040 mL 1.0079 mL 2.5198 mL
15 mM 0.0672 mL 0.3360 mL 0.6720 mL 1.6799 mL
20 mM 0.0504 mL 0.2520 mL 0.5040 mL 1.2599 mL
25 mM 0.0403 mL 0.2016 mL 0.4032 mL 1.0079 mL
30 mM 0.0336 mL 0.1680 mL 0.3360 mL 0.8399 mL
40 mM 0.0252 mL 0.1260 mL 0.2520 mL 0.6300 mL
50 mM 0.0202 mL 0.1008 mL 0.2016 mL 0.5040 mL
60 mM 0.0168 mL 0.0840 mL 0.1680 mL 0.4200 mL
80 mM 0.0126 mL 0.0630 mL 0.1260 mL 0.3150 mL
100 mM 0.0101 mL 0.0504 mL 0.1008 mL 0.2520 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPR7411179330-52-9NAB741SPR 741SPR-741NAB 741NAB-741BacterialAntibioticPotentiatorGram-negativeantibioticcombinationmembranepermeabilityAcrAB-TolCeffluxpumpmultidrug-resistantInhibitorinhibitorinhibit

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