2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Membrane Transporter/Ion Channel Stem Cell/Wnt MAPK/ERK Pathway NF-κB PI3K/Akt/mTOR Apoptosis
  3. Opioid Receptor Toll-like Receptor (TLR) Calcium Channel Potassium Channel IRAK ERK JNK NF-κB Akt Apoptosis
  4. Trimebutine (Standard)

Trimebutine (Standard)  (Synonyms: 曲美布汀(Standard))

目录号: HY-B0380R 纯度: ≥98%
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Trimebutine (Standard)是 Trimebutine (HY-B0380) 的分析标准品。本产品用于研究及分析应用。Trimebutine是阿片受体激动剂，有抗毒蕈碱活性。Trimebutine 是一种多靶点抑制剂和阿片受体 (Opioid Receptor) 激动剂，具有抗毒蕈碱活性。Trimebutine 抑制 L 型钙通道 (L-type Ca2+ channels) 和大电导钙激活钾通道 (BKCa channels)，而抑制细胞外钙内流及钾离子外流。Trimebutine 还靶向 Toll 样受体，抑制 Toll-like receptor 2/4/7/8/9 信号而抑制 LPS 诱导 IRAK1 激活，以及 ERK1/2、JNK 和 NF-κB 的激活，从而发挥抗炎作用。Trimebutine 还通过抑制 AKT/ERK 通路诱导肿瘤细胞凋亡 (apoptosis)。Trimebutine 还抑制平滑肌过度收缩，可用于肠易激综合征 (IBS) 等胃肠道功能紊乱的研究。

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Trimebutine (Standard) Chemical Structure

Trimebutine (Standard) Chemical Structure

CAS No. : 39133-31-8

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规格 价格 是否有货 数量
10 mg ￥300
3 - 5 周
50 mg ￥600
3 - 5 周
100 mg ￥900
3 - 5 周
250 mg ￥1600
3 - 5 周
500 mg ￥2400
3 - 5 周
1 g   询价  
5 g   询价  

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生物活性

Trimebutine (Standard) is the analytical standard of Trimebutine (HY-B0380). This product is intended for research and analytical applications. Trimebutine is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).

分子量

387.47

Formula

C22H29NO5
CAS 号
中文名称

曲美布汀(Standard)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Trimebutine (Standard) 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trimebutine (Standard)39133-31-8曲美布汀(Standard)Opioid ReceptorToll-like Receptor (TLR)Calcium ChannelPotassium ChannelIRAKERKJNKNF-κBAktApoptosisCa2+ channelsCa channelsKcsAInterleukin-1 receptor associated kinaseIL-1R associated kinaseExtracellular signal regulated kinasesc-Jun N-terminal kinaseNuclear factor-κBNuclear factor-kappaBPKBProtein kinase BInhibitorinhibitorinhibit

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