2. Epigenetics
  3. Histone Methyltransferase
  4. UNC8153

UNC8153 是一种强效且选择性的核受体结合 SET 结构域 2（NSD2）的降解剂，Kd 为 24 nM。UNC8153 可降低 NSD2 蛋白（U2OS 细胞中的 DC50 为 0.35 μM）和 H3K36me2 染色质标记的细胞水平。UNC8153 含有一个简单的弹头，可实现蛋白酶体依赖的 NSD2 降解。

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UNC8153 Chemical Structure

UNC8153 Chemical Structure

CAS No. : 2929304-60-7

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规格 价格 是否有货 数量
5 mg ￥995
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10 mg ￥1585
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50 mg ￥4050
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Customer Review

Other Forms of UNC8153:

UNC8153 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].

体外研究
(In Vitro)

UNC8153 (0-20 μM, 96 h) 在 KMS11 细胞中表现出抗粘附作用，并对 MM1S 细胞表现出轻微的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UNC8153 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MM1S
Concentration: 0-50 μM
Incubation Time: 96 h
Result: Inhibited the cell proliferation.
分子量

583.68

Formula

C33H37N5O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

UNC8153 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC81532929304-60-7UNC 8153UNC-8153Histone MethyltransferaseNSD2 degraderH3K36me2proteasome-dependent degradation of NSD2antiproliferative effectsantiadhesive effectsInhibitorinhibitorinhibit

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产品名称：
UNC8153
目录号：
HY-157251A
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