1. Metabolic Enzyme/Protease
  2. HCV Protease
  3. Voxilaprevir

Voxilaprevir (Synonyms: GS-9857)

目录号: HY-19840
产品使用指南

Voxilaprevir (GS-9857) 是一种含氟大环丙型肝炎病毒 (HCV) 非结构蛋白 (NS) 3/4A 蛋白酶抑制剂。对基因型 1-6 HCV 具有很强的体外抗病毒活性,并广泛覆盖 NS3/4A 蛋白酶多态性。GS-9857 提高了对常见的 NS3 抗药性相关突变体 (RAVs) 的覆盖率。

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Voxilaprevir Chemical Structure

Voxilaprevir Chemical Structure

CAS No. : 1535212-07-7

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Description

Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs)[1][2].

IC50 & Target

Hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

868.93

Formula

C₄₀H₅₂F₄N₆O₉S

CAS No.

1535212-07-7

SMILES

O=C([C@H]1N(C([C@@H](NC(O[C@H]2[C@H]3C2)=O)C(C)(C)C)=O)C[C@@](OC4=NC5=CC(OC)=CC=C5N=C4C(F)(CCCC3)F)([H])[C@H]1CC)N[C@]6([C@H](C(F)F)C6)C(NS(=O)(C7(CC7)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Voxilaprevir
目录号:
HY-19840
需求量:

Voxilaprevir

Cat. No.: HY-19840