2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Stem Cell/Wnt JAK/STAT Signaling Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. Bcr-Abl ERK STAT PARP Caspase Apoptosis
  4. VS1150

VS1150 (Compound 11) 是一种靶向 BCR-ABL 的磷酸化诱导嵌合小分子 (PHICS)。VS1150 通过 Y253 位点的抑制性磷酸化 (EC50：69 nM)，显著抑制致癌激酶 BCR-ABL 信号传导，进而引发细胞凋亡 (apoptosis)。VS1150 还能抑制其他致癌 ABL 融合蛋白和耐药突变体，例如 T315I。VS1150 可用于慢性粒细胞白血病 (CML) 和其他 ABL 融合蛋白驱动的癌症研究。

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VS1150 Chemical Structure

VS1150 Chemical Structure

CAS No. : 2855238-97-8

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VS1150 相关抗体

Top Publications Citing Use of Products

查看 Bcr-Abl 亚型特异性产品:

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Abl Bcr-Abl

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

查看 PARP 亚型特异性产品:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VS1150 (Compound 11) is a BCR-ABL-targeting phosphorylation-inducing chimeric small molecule (PHICS). VS1150 significantly inhibits oncogenic kinase BCR-ABL signaling by inducing inhibitory phosphorylation at its Y253 (EC50: 69 nM), subsequently triggering cell apoptosis. VS1150 also inhibits other oncogenic ABL fusions and drug-resistant mutants like T315I. VS1150 can be used for chronic myeloid leukemia (CML) and other ABL fusion-driven cancers research[1].

IC50 & Target

Bcr-Abl

69 nM (EC50)

STAT5

 

Caspase 8

 

分子量

844.58

Formula

C36H38Cl4N12O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VS1150 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VS11502855238-97-8VS 1150VS-1150Bcr-AblERKSTATPARPCaspaseApoptosisExtracellular signal regulated kinasespoly ADP ribose polymerase Phosphorylation-inducing chimeric small moleculePHICSBCR-ABLCMLK562 cellsInhibitorinhibitorinhibit

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