2. NF-κB PI3K/Akt/mTOR Epigenetics
  3. Keap1-Nrf2 AMPK
  4. YPLP

YPLP 是一种酵母衍生肽 Tyr-Pro-Leu-Pro，通过 Nrf2- 和 AMP 激活蛋白激酶 (AMPK) 通路发挥抗疲劳机制活性。YPLP 具有口服活性。

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Custom Peptide Synthesis

YPLP Chemical Structure

YPLP Chemical Structure

CAS No. : 2414391-44-7

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规格 是否有货
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Customer Review

YPLP 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active[1].

体内研究
(In Vivo)

YPLP (10-50 mg/kg，灌胃，共四周) 通过 Nrf2/Keap1 通路减少脂质氧化并增加肌肉组织中的抗氧化酶活性，从而减轻 ICR 小鼠体内由运动引起的氧化损伤[1]。
YPLP (10-50 mg/kg，灌胃，共四周) 通过 AMPK 磷酸化和提高 AMPK 蛋白水平改善疲劳 ICR 小鼠的 ATP 水平和能量代谢[1]。
YPLP (10-50 mg/kg，灌胃，共四周) 调节差异丰度蛋白 (DAP) 的表达，参与蛋白质合成/降解、肌肉动力学和核转运过程，从而调节疲劳小鼠的肌肉功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[1]
Dosage: 10-50 mg/kg/d
Administration: i.g. for 4 weeks
Result: Increased levels of Nrf2, ATP, pAMPK and decreased levels of Keap1.
分子量

488.58

Formula

C25H36N4O6
CAS 号
Sequence

Tyr-Pro-Leu-Pro
Sequence Shortening

YPLP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YPLP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YPLP2414391-44-7Keap1-Nrf2AMPKAMP-activated protein kinaseantifatigueICR miceInhibitorinhibitorinhibit

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