1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. ROS
    Apoptosis
  3. Ziyuglycoside II

Ziyuglycoside II 

目录号: HY-N0332
产品使用指南

Ziyuglycoside II 是从 Sanguisorba officinalis L. 中提取的三萜皂苷化合物。Ziyuglycoside II 诱导活性氧 (ROS) 产生和凋亡 (apoptosis)。 具有抗炎和抗癌作用。

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Ziyuglycoside II Chemical Structure

Ziyuglycoside II Chemical Structure

CAS No. : 35286-59-0

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Description

Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1].

In Vitro

Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively[1].
Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h[1].
Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells[1].
Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent[1].

Cell Viability Assay[1]

Cell Line: MDA-MB-435 cells
Concentration: 10, 20, 30, 40, 50, 60 μM
Incubation Time: 24 hours and 48 hours
Result: The IC50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-435 cells
Concentration: 5, 10, 25 μM
Incubation Time: 24 hours
Result: Induced G0/G1 and S phase arrest.

Apoptosis Analysis[1]

Cell Line: MDA-MB-435 cells
Concentration: 5, 10, 25 μM
Incubation Time: 24 hours
Result: The apoptotic rate was significantly increased in comparison to that of the control.

Western Blot Analysis[1]

Cell Line: MDA-MB-435 cells
Concentration: 5, 10, 25 μM
Incubation Time: 24 hours
Result: Treatment resulted in increased expressions of both p53 and p21.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

604.81

Formula

C₃₅H₅₆O₈

CAS No.

35286-59-0

SMILES

C[C@@H]1CC[C@@](CC[C@]2(C)C3=CC[C@@]4([H])[C@@]2(C)CC[C@]5([H])[C@]4(C)CC[C@H](O[C@@]6([H])[C@H](O)[C@@H](O)[C@@H](O)CO6)C5(C)C)(C(O)=O)[C@@]3([H])[C@]1(C)O

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
Ziyuglycoside II
目录号:
HY-N0332
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Ziyuglycoside II

Cat. No.: HY-N0332