α-Conotoxin M I 

α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs^[1][2].

mAChR^[2]; α1β1γδ nAChR^[1]

α-Conotoxin M I interacts with the α-δ site of the AChR through four hydrophobic residues in its N- and C-terminal loops. Furthermore, the key side chains in α-Conotoxin M I localize in a hydrophobic cluster that interacts with hydrophobic and aromatic residues from both the a and d subunits^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1493.72

C₅₈H₈₈N₂₂O₁₇S₄

88217-10-1

GRCCHPACGKNYSC-NH2 (Disulfide bridge:Cys3-Cys8;Cys4-Cys14)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kulak JM, et al. Alpha-conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. J Neurosci. 1997 Jul 15;17(14):5263-70.  [Content Brief]

  [2]. Bren N, et al. Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site. J Biol Chem. 2000 Apr 28;275(17):12692-700.  [Content Brief]