2. PROTAC GPCR/G Protein Neuronal Signaling
  3. PROTACs Adrenergic Receptor
  4. α1A-AR Degrader 9c

α1A-AR Degrader 9c (化合物 9c) 是一种强效的、选择性的、可逆的 α1A-AR (肾上腺素能受体) PROTAC 降解物，其 DC50 为 2.86 μM。α1A-AR Degrader 9c 诱导的 α1A-AR 降解可归因于蛋白酶体降解。α1A-AR Degrader 9c 对 PC-3 细胞的增殖具有抑制作用，其 IC50 为 6.12 μM。α1A-AR Degrader 9c 具有抗肿瘤活性，可用于前列腺癌的研究。

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α1A-AR Degrader 9c Chemical Structure

α1A-AR Degrader 9c Chemical Structure

CAS No. : 2863635-02-1

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规格 价格 是否有货 数量
5 mg ￥8078
3 - 4 周
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α1A-AR Degrader 9c 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research[1].

IC50 & Target

α1A-adrenergic receptor

2.86 μM (DC50)

体内研究
(In Vivo)

α1A-AR Degrader 9c (compound 9c) (50 mg/kg, IP, once daily for 15 days) causes a significant suppression of tumor growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

829.82

Formula

C38H43N11O11
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

α1A-AR Degrader 9c 相关分类

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Keywords:

α1A-AR Degrader 9c2863635-02-1PROTACsAdrenergic ReceptorBeta ReceptorPC-3 cellsHEK293 cellssmall-molecule PROTACsα1A-Adrenergic receptorubiquitylationdegradationprostate cancerInhibitorinhibitorinhibit

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