2. Stem Cell/Wnt TGF-beta/Smad Apoptosis
  3. PKA Apoptosis
  4. 8-Bromo-cAMP

8-Bromo-cAMP  (Synonyms: 8-Br-Camp)

目录号: HY-12306A
产品使用指南

摩尔计算器

8-Bromo-cAMP (8-Br-Camp) 是一种环 AMP 类似物，是一种环 AMP 依赖性蛋白激酶 (PKA) 激活剂。8-Bromo-cAMP 对癌细胞具有抗增殖和促凋亡 (Apoptosis) 作用。

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8-Bromo-cAMP Chemical Structure

8-Bromo-cAMP Chemical Structure

CAS No. : 23583-48-4

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8-Bromo-cAMP 的其他形式现货产品:

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Other Forms of 8-Bromo-cAMP:

8-Bromo-cAMP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells[1][2].

IC50 & Target

PKA[1]
体外研究
(In Vitro)

8-Bromo-cAMP (0.1/0.5 mM) 可增强人新生儿包皮成纤维细胞 (HFF1) 细胞的重编程效率，0.1 mM 8-Bromo-cAMP 与丙戊酸 (HY-10585) (0.5 mM) 具有协同作用 [1]。
8-Bromo-cAMP (20 μM，24 和 48 小时) 诱导食管癌细胞系 (Eca-109) 凋亡[2]。
8-Bromo-cAMP (0.5 mM，2 天) 诱导人子宫内膜基质细胞蜕膜化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8-Bromo-cAMP 相关抗体:
体内研究
(In Vivo)

8-Bromo-cAMP (60 mg/kg/天，腹腔注射，7 天) 可减少 CT26 肿瘤小鼠的肿瘤[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26 tumor mice[4]
Dosage: 60 mg/kg/day
Administration: i.p., 7 days
Result: Decreases amounts of primary CRC tumor nodules and liver metastases.
Reduces vasculogenic mimicry (PAS–CD31 staining of colorectal and intestinal tumors).
Inhibits cAMP and VEGF expression, increases expression of PKA in tumor tissues.
分子量

408.10

Formula

C10H11BrN5O6P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

8-Bromo-cAMP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Bromo-cAMP23583-48-48-Br-CampPKAApoptosisProtein kinase AHFF1Eca-109endometrial stromal cellInhibitorinhibitorinhibit

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