1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

JNJ-61432059 

目录号: HY-111751
产品使用指南

JNJ-61432059 是具有口服活性的、选择性的 AMPAR 的负向调节剂,其对 GluA1/γ-8 的 pIC50 值为9.7。在老鼠的海马体中显示出具有时间和剂量依赖性的AMPA 受体占用情况,在角膜点燃癫痫动物模型中显示出较强的保护作用。

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JNJ-61432059 Chemical Structure

JNJ-61432059 Chemical Structure

CAS No. : 2035814-50-5

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Description

JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].

IC50 & Target

pIC50: 9.7 (AMPAR)[1].

References
Molecular Weight

443.47

Formula

C₂₅H₂₂FN₅O₂

CAS No.

2035814-50-5

SMILES

OC1CCN(C2=NC=CC3=C(C4=CC=C(NC(C5)=O)C5=C4)C(C6=CC=C(F)C=C6)=NN32)CC1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
JNJ-61432059
目录号:
HY-111751
需求量:

JNJ-61432059

Cat. No.: HY-111751