1. Anti-infection
  2. Bacterial

Dianemycin (Synonyms: Nanchangmycin (free acid))

目录号: HY-100528A 纯度: >98.0%
产品使用指南

Dianemycin (Nanchangmycin free base) 由 Streptomyces nanchangensis NS3226 产生的,抑制革兰氏阳性菌。Dianemycin 也是一种抗 Zika 病毒的广谱抗病毒药物。

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Dianemycin Chemical Structure

Dianemycin Chemical Structure

CAS No. : 35865-33-9

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥1908 In-stock
2 mg ¥700 In-stock
5 mg ¥1100 In-stock
10 mg ¥2000 In-stock
50 mg ¥6000 In-stock
100 mg ¥10000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

Dianemycin (Nanchangmycin free base), produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Dianemycin is a broad spectrum antiviral active against Zika virus[2].

IC50 & Target

Bacteria[1]
Zika virus[2]

In Vitro

Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria[1].
Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types[2].

Solvent & Solubility
In Vitro: 

DMSO : 155 mg/mL (178.75 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1533 mL 5.7663 mL 11.5326 mL
5 mM 0.2307 mL 1.1533 mL 2.3065 mL
10 mM 0.1153 mL 0.5766 mL 1.1533 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (2.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.58 mg/mL (2.98 mM); Clear solution

References
Molecular Weight

867.11

Formula

C₄₇H₇₈O₁₄

CAS No.

35865-33-9

SMILES

C[C@H]1[C@@]2(O[C@]([C@@]3([H])O[C@](O)([C@H](C)C[C@@H]3C)CO)([H])C[C@@H]2C)O[C@]([C@]4(O[C@]5(O[C@]([C@H](C)[C@@H](O)C5)([H])[C@@H](C)/C=C(C)/C([C@H](C)C[C@H](C)C(O)=O)=O)CC4)C)([H])C[C@@H]1O[C@@]6([H])O[C@@H]([C@@H](OC)CC6)C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Dianemycin
目录号:
HY-100528A
需求量:

Dianemycin

Cat. No.: HY-100528A