1. GPCR/G Protein
  2. Adrenergic Receptor

Solabegron (Synonyms: GW 427353)

目录号: HY-19436
产品使用指南

Solabegron (GW 427353) 是 β3 肾上腺素能受体 (β3-AR) 的选择性激动剂, 在中国仓鼠卵巢细胞中测得的 EC50 值为22 nM。目前正在被用于开发治疗膀胱过度活跃和肠易激综合征。

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Solabegron Chemical Structure

Solabegron Chemical Structure

CAS No. : 252920-94-8

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Description

Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM[1]. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome[1].

IC50 & Target

EC50: 22 nM (β3-AR in cells)[1].

In Vivo

Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity[1].

Animal Model: Adult female beagle dogs (6-10 kg)[1].
Dosage: 1, 3 mg/kg.
Administration: I.V. once.
Result: Dosage of 3 mg/kg evoked an increase in micturition volume threshold.
References
Molecular Weight

410.89

Formula

C₂₃H₂₃ClN₂O₃

CAS No.

252920-94-8

SMILES

O=C(C1=CC(C2=CC=CC(NCCNC[C@@H](C3=CC=CC(Cl)=C3)O)=C2)=CC=C1)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
Solabegron
目录号:
HY-19436
需求量:

Solabegron

Cat. No.: HY-19436