Laduviglusib  (Synonyms: CHIR-99021; CT99021)

Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

Laduviglusib (GMP) (20 μM，21 天) 将小鼠成纤维细胞转分化为神经元 (TAUEGFP-/TUJ1 阳性神经元细胞数量的增加)^[1]。
Laduviglusib (GMP) (3-5 μM，2 天) 诱导体细胞向多能干细胞 (PS) 分化 (详细方法参见参考文献)^[2]。
Laduviglusib (GMP) (12 μM，5 天) 将人类成纤维细胞 (HFF) 转化为功能性心肌细胞^[3]。
Laduviglusib (GMP) (3 μM，4 天，hESC) 激活经典 WNT 信号通路，由 β-catenin 易位到细胞核^[4]。
Laduviglusib (GMP) (在表达 MyoD 的 MEF 中) 可增强由 RepSox (GMP) (HY-13012G) 和 Forskolin (HY-15371) 共同作用所导致的增殖细胞数量的显著增加^[5]。
Laduviglusib (GMP) (5 μM，1 天) 可用于从人类化学诱导多能干细胞 (hCiPSC) 生成胰岛 (hCiPSC-islets)^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

465.34

C₂₂H₁₈Cl₂N₈

252917-06-9

固体

White to off-white

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li X, et al. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015;17(2):195-203.  [Content Brief]

  [2]. Guan J et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022;605(7909):325-331.  [Content Brief]

  [3]. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016;352(6290):1216-1220.  [Content Brief]

  [4]. Choi IY, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Rep. 2016;15(10):2301-2312.  [Content Brief]

  [5]. Bar-Nur O, et al. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 May 8;10(5):1505-1521.  [Content Brief]

  [6]. Zhao J, et al. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nat Med. 2022 Feb;28(2):272-282.  [Content Brief]