1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

5-HT Receptor

5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, including glutamate, GABA, dopamine, epinephrine / norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin, cortisol, corticotropin, and substance P, among others. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

5-HT Receptor 相关产品 (231):

Cat. No. Product Name Effect Purity
  • HY-17366
    Clozapine N-oxide Antagonist 99.63%
    Clozapine N-oxide 是 Clozapine 的惰性代谢物,Clozapine 是一种有效的 5-HT1C 受体拮抗剂。Clozapine N-oxide (CNO) 是一种 DREADD 激动剂。
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.83%
    Chlorpromazine Hydrochloride 是一种有效的 dopamine D2 受体,5-HT2A 受体,potassium channelsodium channel 的拮抗剂,抑制 D2 受体和 serotonin 5-HT2A 受体的活性,Ki 值分别为 363 nM 和 8.3 nM。
  • HY-14557
    Pimavanserin Inhibitor 99.73%
    Pimavanserin 是一种有效的 5-hydroxytryptamine (5-HT)2A 受体反向激动剂,在细胞功能测定受体选择和扩增技术 (R-SAT) 中,具有有效的反向激动剂活性,平均 pIC50 为 8.7。
  • HY-N0737A
    Harmine Inhibitor 99.58%
    去氢骆驼蓬碱 (Harmine) 是一种天然生物碱,分离自骆驼蓬种子,常用于抗焦虑研究。
  • HY-N0296A
    Scopolamine hydrobromide Inhibitor >98.0%
    Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3 受体反应,IC50 为 2.09 μM。
  • HY-N0066
    Eucalyptol Inhibitor >98.0%
    Eucalyptol 是 5-HT3 受体, 钾通道, TNF-αIL-1β 的抑制剂。
  • HY-112061
    8-OH-DPAT Agonist >98.0%
    8-OH-DPAT 是一种有效的,选择性的 5-HT 激动剂,对 5-HT1A 的 pIC50 值为 8.19,对 5-HT7 的 Ki 值为 466 nM,对 5-HT1B (pIC50, 5.42) 和 5-HT (pIC50 <5) 的作用很弱。
  • HY-107836
    Methiothepin mesylate Antagonist 99.32%
    Methiothepin mesylate 是一种有效的,非选择性的 5-HT2 receptor 拮抗剂,pKd 值为 7.10 (5-HT1A),7.28 (5HT1B),7.56 (5HT1C),6.99 (5HT1D),7.0 (5-HT5A),7.8 (5-HT5B),8.74 (5-HT6) 和 8.99 (5-HT7),pKi 值为 8.50 (5HT2A),8.68 (5HT2B) 和 8.35 (5HT2C)。
  • HY-15780
    Brexpiprazole Modulator 99.38%
    Brexpiprazole 是一种有效的 人5-羟色胺(5-HT) 5-HT1A (Ki=0.12 nM) 和多巴胺 D2L (Ki=0.3 nM) 受体激动剂,且是 5-HT2A 受体拮抗剂(Ki=0.47 nM)。
  • HY-N0060A
    Ferulic acid sodium Activator 99.74%
    Ferulic acid (sodium) 是一种酚类化合物,能够抑制由氧化应激和炎症产生的机体紊乱。
  • HY-14546
    Aripiprazole Agonist 99.93%
    Aripiprazole(Abilify)是人5-HT1A受体部分激动剂,Ki为4.2 nM。
  • HY-11018
    Risperidone Inhibitor 99.16%
    Risperidone(R64766)是5-HT2受体阻断剂和多巴胺D2受体拮抗剂,Ki值分别为0.16和1.4nM。
  • HY-14763A
    Cariprazine hydrochloride Modulator 99.89%
    Cariprazine(RGH188)盐酸盐有抗精神病活性,对D3和D2受体有较高亲和力,Ki分别为0.09 nM和0.5 nM,对5-HT(1A)受体有一定亲和力。
  • HY-14763
    Cariprazine Modulator 98.01%
    Cariprazine 是一种新型的抗精神病试剂,高亲和力作用于 D3 (Ki=0.085 nM) 和 D2 (Ki=0.49 nM) 受体,稍低亲和力作用于 5-HT1A 受体 (Ki=2.6 nM)。
  • HY-B0965
    Thioridazine hydrochloride Antagonist 99.93%
    Thioridazine是一种治疗精神类疾病的药物, 如精神分裂症, 具有多巴胺D4受体选择性和5-羟色胺拮抗作用。
  • HY-14338A
    Lu AE58054 Hydrochloride Antagonist 99.17%
    Lu AE58054盐酸盐是高活性5-HT(6)R选择性抑制剂,Ki为0.83 nM。
  • HY-A0008
    B-HT 920 Antagonist 99.99%
    B-HT 920(Talipexole 2Hcl)是多巴胺D2受体和α2-肾上腺素受体激动剂,5-HT3受体拮抗剂,有抗帕金森病活性。
  • HY-16978
    TG6-10-1 Antagonist 99.28%
    TG6-10-1是一种EP2拮抗剂, 低nM时只有效作用于EP2, 比作用于人EP3, EP4和IP受体选择性高300, EP1受体选择性高100倍的。
  • HY-B1272
    Desipramine hydrochloride Inhibitor 99.68%
    Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET), 5-羟色胺转运体 (SERT) 和多巴胺转运 (DAT) 的抑制剂,其 Ki 值分别为 4, 61 和 78,720 nM。
  • HY-14541
    Olanzapine Antagonist 99.94%
    Olanzapine(LY170053)是5-HT2和D2受体高亲和性拮抗剂。
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