1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)

Eukaryotic Initiation Factor (eIF)

Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of the functional ribosome around the start codon and also provide regulatory mechanisms in translation initiation.

Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, thus regenerating the active [eIF2.GTP] complex that is required for peptide-chain initiation. The activity of eIF2B is a key control point for eukaryotic protein synthesis and is altered in response to viral infection, hormones, nutrients, growth factors and certain stresses.

Eukaryotic translation initiation factor 4E (eIF4E) is best known for its function in the initiation of protein synthesis on capped mRNAs in the cytoplasm. Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome.

Eukaryotic Initiation Factor (eIF) 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-19831
    4EGI-1 Inhibitor >98.0%
    4EGI-1抑制eIF4E与eIF4G相互作用,作用于HNE1细胞72小时 IC50值为 50μM。
  • HY-14427
    4E1RCat Inhibitor 98.20%
    4E1RCat能抑制eIF4E与eIF4G的相互作用及eIF4E与4E-BP1的相互作用,可抑制eIF4G和eIF4E的结合,IC50为3.2 μM。
  • HY-100733
    4E2RCat Inhibitor >98.0%
    4E2RCat是eIF4E-eIF4G相互作用的抑制剂,IC50值为13.5 μM。
  • HY-16366
    Briciclib Inhibitor 99.15%
  • HY-19560
    SBI-0640756 Inhibitor >98.0%