1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)

Eukaryotic Initiation Factor (eIF)

Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of the functional ribosome around the start codon and also provide regulatory mechanisms in translation initiation.

Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, thus regenerating the active [eIF2.GTP] complex that is required for peptide-chain initiation. The activity of eIF2B is a key control point for eukaryotic protein synthesis and is altered in response to viral infection, hormones, nutrients, growth factors and certain stresses.

Eukaryotic translation initiation factor 4E (eIF4E) is best known for its function in the initiation of protein synthesis on capped mRNAs in the cytoplasm. Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome.

Eukaryotic Initiation Factor (eIF) 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-13251
    Silvestrol Inhibitor 99.28%
    Silvestrol 是一种天然产物,能够抑制 eIF4A 靶作用的转录过程。
  • HY-19831
    4EGI-1 Inhibitor >98.0%
    4EGI-1 是一种 eIF4E/eIF4G 相互作用抑制剂,抑制 eIF4E 结合,Kd 值为 25 μM。
  • HY-14427
    4E1RCat Inhibitor 98.20%
    4E1RCat 是一种 cap 依赖性翻译抑制剂,能够抑制 eIF4E:eIF4GI 相互作用,IC50 值约为 4 μM。
  • HY-100733
    4E2RCat Inhibitor >98.0%
    4E2RCat是eIF4E-eIF4G相互作用的抑制剂,IC50值为13.5 μM。
  • HY-16366
    Briciclib Inhibitor 99.15%
    Briciclib 是一种可溶于水的 ON 013100 衍生物,具有靶作用于 eIF4E 对抗固体肿瘤的潜力。
  • HY-19560
    SBI-0640756 Inhibitor >98.0%
    SBI-0640756 是一种溶于水的 eIF4G1 抑制剂,能够破坏 eIF4F 复合体。
  • HY-15359
    Episilvestrol Inhibitor
    Episilvestrol 是 silvestrol 的衍生物,从 Aglaia silvestris 中分到,能够抑制 eIF4A 靶作用的转录过程。
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