1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)

Eukaryotic Initiation Factor (eIF)

Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of the functional ribosome around the start codon and also provide regulatory mechanisms in translation initiation.

Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, thus regenerating the active [eIF2.GTP] complex that is required for peptide-chain initiation. The activity of eIF2B is a key control point for eukaryotic protein synthesis and is altered in response to viral infection, hormones, nutrients, growth factors and certain stresses.

Eukaryotic translation initiation factor 4E (eIF4E) is best known for its function in the initiation of protein synthesis on capped mRNAs in the cytoplasm. Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome.

Eukaryotic Initiation Factor (eIF) 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-14427
    4E1RCat Inhibitor 98.20%
    4E1RCat能抑制eIF4E与eIF4G的相互作用及eIF4E与4E-BP1的相互作用,可抑制eIF4G和eIF4E的结合,IC50为3.2 μM。
  • HY-19560
    SBI-0640756 Inhibitor >98.0%
    SBI-0640756是eIF4G1的抑制剂,能够扰乱eIF4F的合成,SBI-756也能抑制AKT和NF-κB信号通路。