1. MAPK/ERK Pathway
  2. Mixed Lineage Kinase

Mixed Lineage Kinase

Mixed lineage kinases (MLKs) are mitogen activated protein kinase kinase kinases (MAPKKKs) with features of both serine-threonine and tyrosine kinases that regulate the c-Jun N-terminal kinase (JNK) mitogen activated protein kinase (MAPK) signaling cascade, and also regulate p38 and extracellular signal-regulated kinase (ERK).

MLK3 (MAP3K11) is the most widely expressed MLK family member, and is expressed in neurons (as well as other cell types). At the cellular level, MLK3 is activated by stress, including reactive oxygen species, ceramide, and TNFα. At the molecular level, it is activated by Cdc42 and Rac, which interact with MLK3, and can cause it to dimerize via a leucine zipper interface, resulting in autophosphorylation and enzyme activation.

Mixed Lineage Kinase 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-100573
    Necrosulfonamide Inhibitor 98.00%
    Necrosulfonamide是一个MLKL药理抑制剂, 在HT-29细胞的 IC50是 124 nM.
  • HY-12599
    URMC-099 Inhibitor 99.82%
    URMC-099是MLK3口服活性,脑渗透性抑制剂,IC50值14nM,抑制脂多糖诱导的小胶质细胞TNF的释放。