1. MAPK/ERK Pathway
  2. Mixed Lineage Kinase

Mixed Lineage Kinase

Mixed lineage kinases (MLKs) are mitogen activated protein kinase kinase kinases (MAPKKKs) with features of both serine-threonine and tyrosine kinases that regulate the c-Jun N-terminal kinase (JNK) mitogen activated protein kinase (MAPK) signaling cascade, and also regulate p38 and extracellular signal-regulated kinase (ERK).

MLK3 (MAP3K11) is the most widely expressed MLK family member, and is expressed in neurons (as well as other cell types). At the cellular level, MLK3 is activated by stress, including reactive oxygen species, ceramide, and TNFα. At the molecular level, it is activated by Cdc42 and Rac, which interact with MLK3, and can cause it to dimerize via a leucine zipper interface, resulting in autophosphorylation and enzyme activation.

Mixed Lineage Kinase 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-100573
    Necrosulfonamide Inhibitor 98.00%
    Necrosulfonamide是一种坏死性凋亡抑制剂,通过选择性靶向 ((MLKL)) 来阻断坏死体形成。
  • HY-12599
    URMC-099 Inhibitor 99.90%
    URMC-099是MLK3口服活性,脑渗透性抑制剂,IC50值14nM,抑制脂多糖诱导的小胶质细胞TNF的释放。
  • HY-101524
    TC13172 Inhibitor
    TC13172 是 MLKL 的抑制剂,作用于 HT-29 细胞,其 EC50 值为 2 nM。
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