1. Metabolic Enzyme/Protease
  2. PDHK

PDHK

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDH kinase; PDHK; PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. PDH catalyzes the conversion of pyruvate to acetyl-coenzyme A, which enters into the Krebs cycle, providing ATP to the cell. PDH activity is under the control of pyruvate dehydrogenase kinases (PDHKs).

PDHK 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-N0645
    Dicoumarol Inhibitor 98.70%
    Dicoumarol 是 NAD(P)H: 醌氧化还原酶 1 (NQO1) 和 PDK1 的抑制剂,IC50 值分别为 0.37 和 19.42 μM。
  • HY-12492
    VER-246608 Inhibitor 99.03%
    VER-246608 是一种有效的,ATP 竞争性的丙酮酸脱氢酶激酶 (PDK) 抑制剂,抑制 PDK-1PDK-3PDK-2,和 PDK-4IC50 分别为 35 nM,40 nM,84 nM 和 91 nM。
  • HY-16082
    AZD7545 Inhibitor 99.84%
    AZD7545是PDHK抑制剂,对PDHK1和PDHK2的IC50分别为36.8 nM和6.4 nM。
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