2. Apoptosis JAK/STAT Signaling
  3. PKD Pim Apoptosis
  4. CRT0066101

CRT0066101 是一种有效的具有口服活性的 PKD 抑制剂，对 PKD1、PKD2 和 PKD3 的 IC50 值分别为 1 nM、2.5 nM 和 2 nM。CRT0066101 也是一种有效的 PIM2 抑制剂，IC50 约为 135.7nM。CRT0066101 具有抗癌作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

CRT0066101 Chemical Structure

CRT0066101 Chemical Structure

CAS No. : 956123-34-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

CRT0066101 的其他形式现货产品:

Customer Review

Other Forms of CRT0066101:

CRT0066101 相关抗体

Top Publications Citing Use of Products

查看 PKD 亚型特异性产品:

查看所有亚型
PKD1 PKD2 PKD3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CRT0066101 is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively[1]. CRT0066101 is also a potent PIM2 inhibitor with an IC50 of ~135.7 nM. CRT0066101 has anticancer effects[2].

IC50 & Target[1][2]

PKD1

1 nM (IC50)

PKD2

2.5 nM (IC50)

PKD3

2 nM (IC50)

PIM2

135.7 nM (IC50)

体外研究
(In Vitro)

CRT0066101 (5 µM; 1 h) 可阻断 Panc-1 和 Panc-28 细胞中基础和 NT 诱导的 pS916-PKD1/2（激活的 PKD1/2）。CRT0066101 消除 NT 诱导的 Hsp27 (pS82-Hsp27) 磷酸化，减弱 PKD1 介导的 NF-κB 激活，并消除 NF-κB 依赖性增殖和促生存蛋白的表达[1] .
CRT0066101 显着抑制 Panc-1 细胞增殖，IC50 值为 1 µM。CRT0066101 可诱导 Panc-1 细胞凋亡 6-10 倍。CRT0066101 显着降低 Colo357、Panc-1、MiaPaCa-2 和 AsPC-1 细胞的增殖，但对 Capan-2 细胞有一定影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CRT0066101 相关抗体:

Western Blot Analysis[1]

Cell Line: Panc-1 and Panc-28 cells stimulation with neurotensin (NT)
Concentration: 5 µM
Incubation Time: 1 h
Result: Blocked both the basal and NT-induced pS916-PKD1/2 (activated PKD1/2).
体内研究
(In Vivo)

CRT0066101（80 mg/kg/天；口服灌胃；每天一次；持续 21 天）在 Panc-1 原位模型中可有效阻止体内肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CR-UK nu/nu mice injected with Panc-1 cells[1]
Dosage: 80 mg/kg/day
Administration: Oral gavage; once daily; for 21 days
Result: Potently blocked tumor growth in vivo.
分子量

338.41

Formula

C18H22N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CRT0066101 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRT0066101956123-34-5CRT 0066101CRT-0066101PKDPimApoptosisProtein kinase DPim kinasesPKD1PKD2PKD3PIM2anticancer effectspS82-Hsp27Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CRT0066101
目录号：
HY-15698
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z