1. Protein Tyrosine Kinase/RTK
  2. ROS


ROS is a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. ROS kinase is one of the last two remaining orphan receptor tyrosine kinases. It is thought also that c-ROS gene may have a role in some cardiovascular diseases, and the fact that homozygous male mice targeted against c-ROS gene are healthy but infertile, has inspired researchers to think about ROS inhibition as a method for development of new male contraceptives. The new selective and potent inhibitors for ROS kinase, along with the development of new specific diagnostic methods for the detection of ROS fusion proteins, raises the importance of using these selective inhibitors for targeting ROS mutations as a new method for treatment of cancers harboring such genes.

ROS 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-12678
    Entrectinib Inhibitor 99.61%
    Entrectinib是有效,有口服活性的Trk, ROS1, 和ALK抑制剂;抑制TrkA, TrkB, TrkC, ROS1和 ALK的IC50值分别为1, 3, 5, 12 和7 nM。
  • HY-103022
    Repotrectinib Inhibitor 99.91%
    Repotrectinib (TPX-0005) 是一种有效的 ALK/ROS1/TRK 抑制剂,对 SRC,野生型 WT ALK,突变型 ALK G1202R 和 ALK L1196M 的 IC50 值分别为 5.3 nM,1.01 nM,1.26 nM 和 1.08 nM。
  • HY-N0154
    Neohesperidin dihydrochalcone Inhibitor 98.04%
    Neohesperidin dihydrochalcone是一种合成的糖苷查耳酮,作为低热量人造甜味剂添加到各种食品和饮料中。
  • HY-111416
    WY-135 Inhibitor
    WY-135是ALK (IC50=1.4 nM) 和 ROS1 (IC50=1.1 nM) 的双抑制剂。
  • HY-N1778
    3,4-Dimethoxycinnamic acid Inhibitor 99.54%
    3,4-Dimethoxycinnamic acid (O-Methylferulic acid) 是从 Securidaca inappendiculata 中提取和纯化的单体。3,4-Dimethoxycinnamic acid 通过 ROS 介导的信号途径对 L-02 细胞发挥抗凋亡作用。
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