1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)

Toll-like Receptor (TLR)

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals. TLRs are evolutionarily conserved receptors are homologues of the Drosophila Toll protein, discovered to be important for defense against microbial infection. TLRs recognize highly conserved structural motifs known as pathogen-associated microbial patterns (PAMPs), which are exclusively expressed by microbial pathogens.

Toll-like Receptor (TLR) 相关产品 (31):

Cat. No. Product Name Effect Purity
  • HY-11109
    TAK-242 Inhibitor 99.95%
    TAK-242 是一种有效的 TLR4 抑制剂,选择性抑制 TLR4 调节的细胞因子和 NO 产生。
  • HY-17589
    Chloroquine diphosphate Inhibitor 99.94%
    Chloroquine diphosphate 为一种抗疟疾药,是 autophagy/lysosome 的抑制剂,能够抑制 TLR 的信号传导。
  • HY-13740
    Resiquimod Agonist 99.77%
    Resiquimod 是有效的 TLR7/TLR8 激动剂,可以诱导 TNF-α,IL-6 和 IFN-α 等细胞因子水平变化。
  • HY-B0180
    Imiquimod Agonist 99.57%
    Imiquimod 是一种免疫反应调节剂,作为 toll-like receptor 7 的激动剂起作用。
  • HY-100461
    C29 Inhibitor >98.0%
    C29是潜在的TLR2抑制剂。
  • HY-100442
    Paquinimod 98.38%
    Paquinimod 是一种 S100A9 抑制剂,阻止 S100A9 与 TLR-4 结合。
  • HY-101929
    CU-CPT17e Agonist 98.02%
    CU-CPT17e 是一种多 Toll 样受体 (TLR) 激动剂,可激活 TLR3TLR8TLR9
  • HY-103698A
    TLR7/8 agonist 1 dihydrochloride Agonist 98.02%
    TLR7/8 agonist 1 dihydrochloride 是一种 toll 样受体 (TLR7)/TLR8 的双重激动剂。
  • HY-15601
    GS-9620 Agonist 98.78%
    GS-9620 是一种有效的选择性的 Toll 样受体 (Toll-Like Receptor (TLR)7) 激动剂。
  • HY-13773
    Motolimod Agonist 98.83%
    Motolimod 选择性的Toll样受体 (Toll-like receptor,TLR8) 激动剂,EC50 约为 100 nM。
  • HY-B1370
    Hydroxychloroquine sulfate Inhibitor 99.99%
    Hydroxychloroquine sulfate 是一种合成的抗疟疾药物,也可以抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。
  • HY-N0201
    Atractylenolide I Antagonist 99.08%
    白术内酯I(Atractylenolide-I)是从白术中提取的一种天然化合物,可诱导细胞凋亡而导致HL-60细胞的细胞毒性,TLR4拮抗剂。
  • HY-N0741
    Leonurine Inhibitor 99.45%
    Leonurine 是从益母草中分离到的主要生物碱类化合物,具有抗炎功效。
  • HY-108471
    CU CPT 22 Inhibitor >99.0%
    CU CPT 22 是一种 toll 样受体 1 和 2 (TLR1/2) 抑制剂, 其 IC50 值为 0.58 μM。
  • HY-12756A
    E6446 dihydrochloride Antagonist
    E6446二盐酸盐是Toll样受体(TLRs)抑制剂,HEK:TLR9细胞中IC50值为10nM。
  • HY-103697A
    Gardiquimod trifluoroacetate Agonist 99.28%
    Gardiquimod trifluoroacetate 是一个特异的 TLR7 激动剂,也能抑制 HIV-1 逆转录酶。
  • HY-N0741A
    Leonurine hydrochloride Inhibitor 99.32%
    Leonurine hydrochloride 是从益母草中分离到的主要生物碱类化合物,具有抗肿瘤作用。
  • HY-N0795
    Procyanidin B1 Antagonist 99.92%
    Procyanidin B1能够在Huh-7细胞中,分别以IC50 29μM和15μM 抑制感染疱疹性口炎病毒和丙肝病毒。
  • HY-10018
    Toll-like receptor modulator Modulator 99.40%
    Toll-like receptor modulator是Toll-like受体调节剂。
  • HY-100176
    PF-4878691 Agonist 99.89%
    PF-4878691 是一种有效且有选择性的 Toll 样受体 7 (TLR7) 激动剂。
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