1. Signaling Pathways
  2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)

Toll-like Receptor (TLR)

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals. TLRs are evolutionarily conserved receptors are homologues of the Drosophila Toll protein, discovered to be important for defense against microbial infection. TLRs recognize highly conserved structural motifs known as pathogen-associated microbial patterns (PAMPs), which are exclusively expressed by microbial pathogens.

Toll-like Receptor (TLR) 相关产品 (36):

Cat. No. Product Name Effect Purity
  • HY-11109
    Resatorvid Inhibitor 99.95%
    Resatorvid (TAK-242) 是一种有效的 TLR4 信号传导抑制剂,可选择性地抑制TLR-介导的细胞因子和一氧化氮的产生。
  • HY-17589
    Chloroquine diphosphate Inhibitor 99.94%
    Chloroquine diphosphate是一种广泛用于治疗疟疾和类风湿性关节炎的抗疟疾和抗炎药。 Chloroquine 是 autophagytoll-like receptors (TLRs) 的抑制剂。
  • HY-13740
    Resiquimod Agonist 99.85%
    Resiquimod是一种Toll样受体7和8 (TLR7/TLR8) 的激动剂, 诱导细胞因子如TNF-α,IL-6和IFN-α的上调。
  • HY-100461
    C29 Inhibitor >98.0%
    C29是Toll样受体2 (Toll-like receptor 2 (TLR2)) 抑制剂。
  • HY-B1370
    Hydroxychloroquine sulfate Inhibitor 99.99%
    Hydroxychloroquine sulfate 是一种合成的抗疟疾药物,也可以抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。
  • HY-128598
    MD2-TLR4-IN-1 Inhibitor
    MD2-TLR4-IN-1 (compound 22m) 是 MD2-TLR4 复合体的抑制剂,能够抑制巨噬细胞 LPS 诱导的 TNF-α 和 IL-6 的表达,IC50 值分别为 0.89 μM 和 0.53 μM。
  • HY-N6673
    Okanin Inhibitor
    Okanin 是 Coreopsis tinctoria 的有效成分。Okanin 通过抑制 TLR4/NF-κB 信号通路减弱 LPS 诱导的小胶质细胞活化。
  • HY-N0703
    Schaftoside Inhibitor
    Schaftoside 是在多种中草药(如 Eleusine indica)中发现的黄酮类化合物。Schaftoside 抑制 TLR4 和 Myd88 表达。 Schaftoside 还降低 Drp1 表达和磷酸化,并减少线粒体分裂。
  • HY-B0180
    Imiquimod Agonist 99.37%
    Imiquimod (R 837) 是一种免疫反应调节剂,作为 toll-like receptor 7 的激动剂起作用。
  • HY-15601
    Vesatolimod Agonist 99.56%
    Vesatolimod (GS-9620) 是一种有效,选择性,可口服的 Toll 样受体7 (TLR7) 激动剂,EC50 值为291 nM。
  • HY-13773
    Motolimod Agonist 98.83%
    Motolimod 是选择性的Toll样受体 8 (TLR8) 激动剂,EC50约为 100 nM。
  • HY-108471
    CU-CPT22 Inhibitor >99.0%
    CU-CPT22 是一种 toll 样受体 1 和 2 (TLR1/2) 抑制剂, 其 IC50 值为 0.58 μM。
  • HY-N0201
    Atractylenolide I Antagonist 99.08%
    Atractylenolide I 是从白术根中得到的倍半萜烯,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。Atractylenolide I 为 TLR4 的拮抗剂,同时在 A375 细胞中,能够降低 JAK2STAT3 的磷酸化水平。
  • HY-12756A
    E6446 dihydrochloride Antagonist 99.96%
    E6446 dihydrochloride 是一种有效的、可口服的 TLR7TLR9 拮抗剂,可用于有害炎症反应的研究。
  • HY-103698A
    TLR7/8 agonist 1 dihydrochloride Agonist 98.02%
    TLR7/8 agonist 1 dihydrochloride 是一种 toll 样受体 (TLR7)/TLR8 的双重激动剂。
  • HY-100442
    Paquinimod 98.38%
    Paquinimod 是一种 S100A9 抑制剂,阻止 S100A9 与 TLR-4 结合。
  • HY-101929
    CU-CPT17e Agonist 98.02%
    CU-CPT17e 是一种多 Toll 样受体 (TLR) 激动剂,可激活 TLR3TLR8TLR9
  • HY-103697A
    Gardiquimod trifluoroacetate Agonist 99.28%
    Gardiquimod trifluoroacetate 是一个特异的 TLR7 激动剂,也能抑制 HIV-1 逆转录酶。
  • HY-109104
    Telratolimod Agonist >98.0%
    Telratolimod 是一种 TLR7/8 激动剂,具有抗肿瘤活性。
  • HY-103483
    MD2-IN-1 Inhibitor 99.85%
    MD2-IN-1 是髓样分化蛋白 2 (MD2) 的抑制剂,对重组人 MD2 (rhMD2) 的 KD 值为 189 μM。
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