2. Autophagy MAPK/ERK Pathway GPCR/G Protein
  3. ULK Ras
  4. DCC-3116

DCC-3116 是一种口服活性 ULK1/2 抑制剂。DCC-3116 可通过抑制 KRASG12C 信号传导来促进肺癌细胞自噬，从而抑制肺癌细胞的增殖，发挥抗癌作用。

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DCC-3116 Chemical Structure

DCC-3116 Chemical Structure

CAS No. : 2543673-19-2

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规格 价格 是否有货
1 mg ￥1500
询问价格 & 货期
5 mg ￥3300
询问价格 & 货期
10 mg ￥5200
询问价格 & 货期

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Customer Review

DCC-3116 相关抗体

Top Publications Citing Use of Products

查看 ULK 亚型特异性产品:

查看所有亚型
ULK1 ULK2

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DCC-3116 is an orally active ULK1/2 inhibitor. DCC-3116 can promote autophagy in lung cancer cells by inhibiting KRASG12C signaling, thereby inhibiting the proliferation of lung cancer cells and exerting anti-cancer effects[1].

IC50 & Target

ULK1

 

ULK2

 

KRas G12C

 

体外研究
(In Vitro)

DCC-3116 (100 nM, 72 h) 单独使用可抑制 NCI-H2122 和 Calu-1 细胞增殖，减少 pS318-ATG13 表达，与 Sotorasib (HY-114277) 联合使用时具有协同作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DCC-3116 相关抗体:
体内研究
(In Vivo)

DCC-3116 (每天服用 3 or 30 mg/kg，连续使用 56 天， p.o. and p.i.) 单独使用或与 Sotorasib (HY-114277) 联合使用都可以抑制 NSCLC 肺癌小鼠模型的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mouse models of NSCLC lung cancer (adult mice were initiated between 6-8 weeks of age) [1]
Dosage: 3 or 30 mg/kg/day for 56 days
Administration: p.o. and p.i
Result: Inhibited mice tumor growth and improved mice survival rate, while significantly reducing mice body weight (>20%).
分子量

535.60

Formula

C26H36F3N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DCC-3116 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCC-31162543673-19-2DCC3116DCC 3116ULKRasUnc-51 like kinasenon-small cell lung cancer (NSCLC)autophagycell proliferationNCI-H2122 cellCalu-1 cellInhibitorinhibitorinhibit

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