1. Metabolic Enzyme/Protease Apoptosis
  2. Proteasome Apoptosis
  3. VR23

VR23有效抑制胰蛋白酶样蛋白酶 (IC50=1nM), 胰凝乳蛋白酶样蛋白酶 (IC50=50-100 nM), 和caspase样蛋白酶 (IC50=3 μM)。

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VR23 Chemical Structure

VR23 Chemical Structure

CAS No. : 1624602-30-7

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ¥605
In-stock
5 mg ¥550
In-stock
10 mg ¥950
In-stock
50 mg ¥3200
In-stock
100 mg ¥5500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC50=1 nM), chymotrypsin-like proteasomes (IC50=50-100 nM), and caspase-like proteasomes (IC50=3 μM).

IC50 & Target

IC50: 1 nM (trypsin-like proteasome), 50-100 nM (chymotrypsin-like proteasome), 3 μM (caspase-like proteasome)

体外研究
(In Vitro)

VR23 is a novel proteasome inhibitor targeting β2 of the 20S proteasome subunit. VR23 produces a synergistic effect in killing multiple myeloma cells, including those that were resistant to PS-341. VR23 as a structurally novel proteasome inhibitor with desirable properties as an anticancer agent.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

VR23 shows effective antitumor and antiangiogenic activities in mice.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

477.88

Formula

C19H16ClN5O6S

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 33.33 mg/mL (69.75 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0926 mL 10.4629 mL 20.9258 mL
5 mM 0.4185 mL 2.0926 mL 4.1852 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0926 mL 10.4629 mL 20.9258 mL 52.3144 mL
5 mM 0.4185 mL 2.0926 mL 4.1852 mL 10.4629 mL
10 mM 0.2093 mL 1.0463 mL 2.0926 mL 5.2314 mL
15 mM 0.1395 mL 0.6975 mL 1.3951 mL 3.4876 mL
20 mM 0.1046 mL 0.5231 mL 1.0463 mL 2.6157 mL
25 mM 0.0837 mL 0.4185 mL 0.8370 mL 2.0926 mL
30 mM 0.0698 mL 0.3488 mL 0.6975 mL 1.7438 mL
40 mM 0.0523 mL 0.2616 mL 0.5231 mL 1.3079 mL
50 mM 0.0419 mL 0.2093 mL 0.4185 mL 1.0463 mL
60 mM 0.0349 mL 0.1744 mL 0.3488 mL 0.8719 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
VR23
目录号:
HY-18741
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