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AZD8329 

目录号: HY-18173
产品使用指南

AZD8329 是一种有效的 11β-羟甾类脱氢酶 1 型 (11β-HSD1) 抑制剂,对人11β-HSD1 的IC50 值为 9 nM,与 11β-HSD2 (IC50 >30 μM)、17β-HSD1 (IC50 >30 μM) 、17β-HSD3 (10 μM 时抑制小于5%) 相比,表现出良好的选择性。

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AZD8329 Chemical Structure

AZD8329 Chemical Structure

CAS No. : 1048668-70-7

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Description

AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2 (IC50 >30 μM), 17β-HSD1 (IC50 >30 μM) and 17β-HSD3 (﹤ 5% inhibition at 10 μM)[1].

IC50 & Target

IC50: 9 nM (human 11β-HSD1)[1]

In Vitro

AZD8329 shows a IC50s of 0.009, 0.0086, 0.008, 0.024, 0.002 and 6.1 μM for human enzyme, rat enzyme, dog enzyme, cyno enzyme, human adipocyte and mouse enzyme, respectively[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (148.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3723 mL 11.8616 mL 23.7231 mL
5 mM 0.4745 mL 2.3723 mL 4.7446 mL
10 mM 0.2372 mL 1.1862 mL 2.3723 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂
(以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.93 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.93 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.93 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

421.53

Formula

C₂₅H₃₁N₃O₃

CAS No.

1048668-70-7

SMILES

O=C(O)C1=CC=C(N2N=CC(C(NC3C(C4)CC5CC4CC3C5)=O)=C2C(C)(C)C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
AZD8329
目录号:
HY-18173
需求量:

AZD8329

Cat. No.: HY-18173