2. Metabolic Enzyme/Protease Anti-infection
  3. Cathepsin SARS-CoV
  4. CTSL/B-IN-1

CTSLCTSB-IN-1 (化合物212-148) 是宿主病毒刺突切割蛋白 CTSL/CTSB 和 TMPRSS2 的双特异性抑制剂，IC50 分别为 2.13/64.07 nM 和 1.38 μM。 CTSLCTSB-IN-1 通过抑制病毒刺突蛋白切割阻断了两条相关的 SARS-CoV-2 病毒进入通路，并可应用于抗 SARS-CoV-2 病毒研究。

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CTSL/B-IN-1 Chemical Structure

CTSL/B-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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CTSL/B-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins CTSL/CTSB and TMPRSS2 with IC50s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research[1].

IC50 & Target

IC50: 1.38 μM (TMPRSS2)[1], IC50: 2.13/64.07 nM (CTSL/CTSB)[1]
体外研究
(In Vitro)

CTSLCTSB-IN-1 (10-3-105 nM,1h) 在临床分离的 SARS-CoV-2 δ 株或 omicron BA.2 株感染的 Calu-3 细胞中显示出显著的抗病毒作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CTSL/B-IN-1 相关抗体:
分子量

765.92

Formula

C41H47N7O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CTSL/B-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CTSL/B-IN-1CathepsinSARS-CoVSARS coronavirusSARS-CoV-2CTSLCTSBTMPRSS2Serine endopeptidasesHuh-7 (JCRB0403) cellsCalu-3InfectionInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-163029
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