2. Stem Cell/Wnt
  3. Wnt
  4. FIDAS-3

FIDAS-3 是一种二苯乙烯衍生物，也是一种强效的 Wnt 抑制剂，对甲硫氨酸腺苷转移酶 2A (MAT2A) 的 IC50 为 4.9 μM。FIDAS-3 与 S-腺苷甲硫氨酸 (SAM) 有效竞争 MAT2A 结合，并具有抗癌活性。

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FIDAS-3 Chemical Structure

FIDAS-3 Chemical Structure

CAS No. : 1266684-01-8

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规格 价格 是否有货 数量
1 mg ￥320
In-stock
5 mg ￥720
In-stock
10 mg ￥1080
In-stock
25 mg ￥2160
In-stock
50 mg ￥3132
In-stock
100 mg ￥4480
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

FIDAS-3 相关抗体

Top Publications Citing Use of Products

查看 Wnt 亚型特异性产品:

查看所有亚型
Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

IC50 & Target

IC50: 4.9 μM (Methionine S-adenosyltransferase 2A (MAT2A))[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
32.1 μM
Compound: 1a
Inhibition of human ERG over-expressed in HEK293 cell membrane by [3H]dofetilide binding assay
Inhibition of human ERG over-expressed in HEK293 cell membrane by [3H]dofetilide binding assay
[PMID: 24950374]
LS174T IC50
26.9 nM
Compound: 1a
Antiproliferative activity against human LS 174T cells by cell viability analyzer
Antiproliferative activity against human LS 174T cells by cell viability analyzer
[PMID: 24950374]
LS174T IC50
59 nM
Compound: 1
Antiproliferative activity against human LS 174T cells after 4 days by Vi-Cell cell viability analyzer
Antiproliferative activity against human LS 174T cells after 4 days by Vi-Cell cell viability analyzer
[PMID: 24930834]
体外研究
(In Vitro)

FIDAS-3 (3 μM；7 天；LS174T 细胞) 处理显著抑制 LS174T 细胞的增殖[1]。
FIDAS-3 (3-10 μM) 处理抑制 LS174T CRC 细胞中的 c-Myc 和细胞周期蛋白 D1。FIDAS-3 诱导细胞周期抑制剂 p21WAF1/CIP1[1] 的表达。
FIDAS-3 (10 μM；36 h) 处理减少 LS174T 细胞中 S-腺苷甲硫氨酸 (SAM) 和 S-腺苷同型半胱氨酸 (SAH) 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FIDAS-3 相关抗体:

Cell Viability Assay[1]

Cell Line: LS174T colorectal cancer (CRC) cells
Concentration: 3 μM
Incubation Time: 7 days
Result: Significantly inhibited the proliferation of LS174T cells.
体内研究
(In Vivo)

FIDAS-3 (20 mg/kg；腹腔注射；每天；1个月；C57BL/6J无胸腺裸鼠) 处理显著抑制异种移植肿瘤的生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J athymic nude mice (6-8 week) injected with LS174 cells[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; daily; for one months
Result: Significantly inhibited the growth of xenograft tumors.
分子量

259.29

Formula

C16H15F2N
CAS 号
性状

固体

颜色

Off-white to light green

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

FIDAS-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FIDAS-31266684-01-8FIDAS3FIDAS 3WntMAT2Aanti-cancerS-adenosylmethionineSAMSAHc-MycCyclinD1anti-proliferationβ-cateninInhibitorinhibitorinhibit

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目录号：
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