2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Flibanserin hydrochloride (propan-2-ol) hydrate

Flibanserin hydrochloride (propan-2-ol) hydrate  (Synonyms: 盐酸氟立班丝氨; BIMT-17 hydrochloride (propan-2-ol) hydrate; BIMT-17BS hydrochloride (propan-2-ol) hydrate)

目录号: HY-A0095A 含量: 99.04%
COA 产品使用指南 技术支持

Flibanserin (BIMT-17) hydrochloride (propan-2-ol) hydrate 是一种具有口服活性的 5- 羟色胺的 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂，结合亲和力 Ki 分别为 1 nM 和 49 nM。Flibanserin hydrochloride (propan-2-ol) hydrate 也能够结合多巴胺 D4 受体，Ki 为 4-24 nM。Flibanserin hydrochloride (propan-2-ol) hydrate 具有抗抑郁和抗焦虑作用，可用于性欲减退 (HSDD) 的研究。

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Flibanserin hydrochloride (propan-2-ol) hydrate Chemical Structure

Flibanserin hydrochloride (propan-2-ol) hydrate Chemical Structure

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100 mg ￥3240
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Customer Review

Other Forms of Flibanserin hydrochloride (propan-2-ol) hydrate:

Flibanserin hydrochloride (propan-2-ol) hydrate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

查看 5-HT Receptor 亚型特异性产品:

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flibanserin (BIMT-17) hydrochloride (propan-2-ol) hydrate is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride (propan-2-ol) hydrate binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride (propan-2-ol) hydrate shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research[1]-[5].

IC50 & Target

5-HT1A Receptor

 

5-HT2A Receptor

 

5-HT1A Receptor

1 nM (Ki)

5-HT2A Receptor

49 nM (Ki)

体外研究
(In Vitro)

Flibanserin (0.01-100 μM；72 小时) hydrochloride (propan-2-ol) hydrate 在氧化降解后可转化为两种无毒性的降解产物 DP1 和 DP2[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flibanserin hydrochloride (propan-2-ol) hydrate 相关抗体:

Cell Viability Assay[1]

Cell Line: NHSF cell lin
Concentration: 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 72 hours
Result: Resulted cell viability reached to 97.91% (DP1) and 96.73% (DP2) at 0.01 μM.
Showed non-toxic up to 100 μM (IC50 >100 μM).
体内研究
(In Vivo)

Flibanserin (1-30 mg/kg；腹腔注射；单剂量) hydrochloride (propan-2-ol) hydrate 在前额皮质、海马和中脑中显示出不同的药理学特性。 5-HT1A受体在皮质中的占据率表明其比其他脑区更敏感[2]。
Flibanserin (15-45 mg/kg；口服；每日两次；22天) hydrochloride (propan-2-ol) hydrate 优先激活属于中脑边缘多巴胺能通路的脑区和参与整合与性动机相关的性线索的下丘脑结构[3]。
Flibanserin (5-50 mg/kg；皮下；单剂量) hydrochloride (propan-2-ol) hydrate 在大鼠超声发声模型中具有抗焦虑作用，且无运动副作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Long Evans female rats (225-250 g)[3]
Dosage: 15 mg/kg; 45 mg/kg
Administration: Oral gavage; twice a day for 22 days
Result: Increased the density of activated catecholaminergic neurons in the ventral tegmental area but not in the locus coeruleus.
Increased Fos expression in the medial preoptic area and arcuate nucleus of the hypothalamus, ventral tegmental area, locus coeruleus, and lateral paragigantocellular nucleus with chronic 22-day treatment.
Animal Model: Rat pup ultrasonic vocalization model of anxiety[4]
Dosage: 5, 10, 25, and 50 mg/kg
Administration: Subcutaneous injection
Result: Reduced ultrasonic vocalizations in rat pups.
Showed effective within 30 min and has no severe locomotor side effects at active doses.
Clinical Trial
分子量

465.20

同用名

盐酸氟立班丝氨; BIMT-17 hydrochloride (propan-2-ol) hydrate; BIMT-17BS hydrochloride (propan-2-ol) hydrate

Formula

C20H22ClF3N4O.0.5C3H8O.0.5H2O
性状

固体

颜色

White to off-white

中文名称

盐酸氟立班丝氨；盐酸氟立班丝胺；盐酸氟利班丝氨
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 99.04%

COA (273 KB)

产品使用指南 (1538 KB)
参考文献

Flibanserin hydrochloride (propan-2-ol) hydrate 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flibanserin hydrochloride (propan-2-ol)BIMT-17 hydrochloride (propan-2-ol)BIMT-17BS hydrochloride (propan-2-ol)盐酸氟立班丝氨盐酸氟立班丝胺盐酸氟利班丝氨5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptoraffinityneurotransmitterhypoactivesexualdesiredisorderantidepressantantianxietyhypoactive sexual desire disorderHSDDorally activeDP1DP2no cytotoxicityNHSF cell lineprefrontal cortexhippocampusmidbrainInhibitorinhibitorinhibit

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