2. Stem Cell/Wnt Metabolic Enzyme/Protease PI3K/Akt/mTOR Neuronal Signaling Apoptosis TGF-beta/Smad GPCR/G Protein NF-κB
  3. Akt Adrenergic Receptor mTOR NF-κB Dopamine β-hydroxylase TGF-beta/Smad Apoptosis PI3K
  4. Fusaric acid (Standard)

Fusaric acid (Standard)  (Synonyms: 萎蔫酸 (Standard))

目录号: HY-128483R 纯度: ≥98%
产品使用指南 技术支持

Fusaric acid (Standard) 是 Fusaric acid (HY-128483) 的分析标准品。本产品用于研究及分析应用。Fusaric acid 是一种口服有效的多通路抑制剂，具有诱导氧化应激和凋亡 (apoptosis) 的活性。Fusaric acid 可螯合二价金属阳离子、损伤线粒体膜结构，激活 Caspase-3/7、-8、-9 等凋亡相关蛋白酶。Fusaric acid 还调节 Bax/Bcl-2 蛋白，抑制 NF-κB、TGF-β1/SMADs 和 PI3K/AKT/mTOR 等纤维化相关信号通路，减少胶原沉积。Fusaric acid 也是一种多巴胺 β-羟化酶 (dopamine β-hydroxylase) 抑制剂，可降低脑、心脏、脾脏和肾上腺中去甲肾上腺素和肾上腺素的内源性水平。Fusaric acid 可在心脏疾病中发挥心肌纤维化、改善心脏肥厚的作用，还能够用于食管癌、肝癌等研究。

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Fusaric acid (Standard) Chemical Structure

Fusaric acid (Standard) Chemical Structure

CAS No. : 536-69-6

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规格 价格 是否有货 数量
5 mg ￥500
3 - 5 周
10 mg ￥770
3 - 5 周
25 mg ￥1400
3 - 5 周
50 mg ￥2100
3 - 5 周
100 mg ￥3150
3 - 5 周
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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生物活性

Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β1/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer.

分子量

179.22

Formula

C10H13NO2
CAS 号
中文名称

萎蔫酸 (Standard)
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Fusaric acid (Standard) 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fusaric acid (Standard)536-69-6萎蔫酸 (Standard)AktAdrenergic ReceptormTORNF-κBDopamine β-hydroxylaseTGF-beta/SmadApoptosisPI3KPKBProtein kinase BBeta ReceptorMammalian target of RapamycinNuclear factor-κBNuclear factor-kappaBDopamine beta-hydroxylaseDopamine beta-monooxygenaseDopamine β-monooxygenaseTransforming growth factor betaPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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