Erbb4 - erb-b2 receptor tyrosine kinase 4 Gene

中文名称：erb-b2 受体酪氨酸激酶4

种属: Mus musculus

同用名: Her4; c-erbB-4

基因 ID: 13869 | 基因类型: protein coding

关于 Erbb4

Chromosome 1: 68,071,345-69,147,218 reverse strand.GRCm39:CM000994.3

This gene has 5 transcripts (splice variants), 227 orthologues, 53 paralogues and is associated with 18 phenotypes. Biased expression in CNS E18 (RPKM 2.3), frontal lobe adult (RPKM 2.1) and 8 other tissues.

功能概要

该基因编码的蛋白可启动蛋白酪氨酸激酶活性。参与多个过程，包括乳腺发育；神经系统发育；氮化合物代谢过程的正向调控。在几个过程的上游或内部起作用，包括细胞对表皮生长因子刺激的反应；肽基酪氨酸自磷酸化；和细胞凋亡过程的调节。位于 GABA 能突触和谷氨酸能突触中。是突触后密度膜的组成部分。是突触前膜的组成部分。以多种结构表达，包括大脑；早孕;胚胎外胚层；心;和乳腺原基。该基因的人类直系同源物与 19 型肌萎缩侧索硬化有关；结直肠癌；食道鳞状细胞癌；肝细胞癌；和肺腺癌。与人 ERBB4（erb-b2 受体酪氨酸激酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein tyrosine kinase activity. Involved in several processes, including mammary gland development; nervous system development; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including cellular response to epidermal growth factor stimulus; peptidyl-tyrosine autophosphorylation; and regulation of apoptotic process. Located in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; heart; and mammary gland primordium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Erbb4 基因产物(1)

mRNA	Protein	Name
NM_010154.2	NP_034284.1	receptor tyrosine-protein kinase erbB-4 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GABA receptor binding	IDA IDA: 通过直接分析推断	24218551	MGI
enables epidermal growth factor receptor activity	IGI IGI: 通过遗传相互作用推断	12621152	MGI
enables neuregulin receptor activity	IDA IDA: 通过直接分析推断	8702723	MGI
enables neuregulin receptor activity	IMP IMP: 通过突变表型推断	19632177	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	16061658	MGI
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	9168114	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERBB2-ERBB4 signaling pathway	IDA IDA: 通过直接分析推断	8702723	MGI
involved in ERBB2-ERBB4 signaling pathway	IGI IGI: 通过遗传相互作用推断	12621152	MGI
involved in ERBB4 signaling pathway	IMP IMP: 通过突变表型推断	16446434	MGI
involved in ERBB4-ERBB4 signaling pathway	IDA IDA: 通过直接分析推断	8702723	MGI
involved in cardiac muscle tissue regeneration	IMP IMP: 通过突变表型推断	19632177	MGI
acts upstream of or within cell fate commitment	IDA IDA: 通过直接分析推断	12399441	MGI
involved in cell surface receptor signaling pathway	IDA IDA: 通过直接分析推断	24218551	MGI
involved in cell surface receptor signaling pathway via JAK-STAT	IMP IMP: 通过突变表型推断	10508857	MGI
acts upstream of or within cellular response to epidermal growth factor stimulus	IDA IDA: 通过直接分析推断	8702723	MGI
involved in central nervous system morphogenesis	IMP IMP: 通过突变表型推断	10655590	MGI
involved in embryonic pattern specification	IMP IMP: 通过突变表型推断	10655590	MGI
acts upstream of or within establishment of planar polarity involved in nephron morphogenesis	IMP IMP: 通过突变表型推断	22076439	MGI
acts upstream of or within heart development	IMP IMP: 通过突变表型推断	7477376	MGI
involved in lactation	IMP IMP: 通过突变表型推断	10508857	MGI
involved in mammary gland alveolus development	IMP IMP: 通过突变表型推断	10508857	MGI
involved in mammary gland epithelial cell differentiation	IMP IMP: 通过突变表型推断	16837552	MGI
acts upstream of or within nervous system development	IMP IMP: 通过突变表型推断	7477376	MGI
involved in neural crest cell migration	IMP IMP: 通过突变表型推断	10655590	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: 通过直接分析推断	22184199	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: 通过突变表型推断	22184199	MGI
involved in olfactory bulb interneuron differentiation	IMP IMP: 通过突变表型推断	15543145	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	16837552	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: 通过突变表型推断	19632177	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: 通过遗传相互作用推断	18458158	MGI
acts upstream of or within positive regulation of protein localization to cell surface	IGI IGI: 通过遗传相互作用推断	18458158	MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT	IMP IMP: 通过突变表型推断	16837552	MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: 通过突变表型推断	16837552	MGI
involved in regulation of cell migration	IMP IMP: 通过突变表型推断	15543145	MGI
involved in synapse assembly	IDA IDA: 通过直接分析推断	20393464	MGI
involved in synapse assembly	IMP IMP: 通过突变表型推断	20393464	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in GABA-ergic synapse	IDA IDA: 通过直接分析推断	20393464	MGI
is active in GABA-ergic synapse	IMP IMP: 通过突变表型推断	20393464	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	20393464	MGI
is active in neuromuscular junction	IDA IDA: 通过直接分析推断	22184199	MGI
is active in neuromuscular junction	IMP IMP: 通过突变表型推断	22184199	MGI
is active in plasma membrane	IDA IDA: 通过直接分析推断	8702723	MGI
is active in postsynaptic density membrane	IDA IDA: 通过直接分析推断	20393464	MGI
is active in presynaptic membrane	IDA IDA: 通过直接分析推断	20393464	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Erbb4 蛋白结构

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

TM_ErbB4

PTKc_HER4

0
200
400
600
800
1000
1200
1292 a.a.

蛋白主名

其他名称

receptor tyrosine-protein kinase erbB-4

avian erythroblastosis oncogene B 4	proto-oncogene-like protein c-ErbB-4
v-erb-a erythroblastic leukemia viral oncogene homolog 4

Erbb4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Erbb4	Q61527	WWOX	Homo sapiens	Q9NZC7	Confocal	16061658
种属间	Erbb4	Q61527	WWOX	Homo sapiens	Q9NZC7	Anti Tag CoIP	16061658

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	作用方式	纯度	是否罕见病
HY-13272	Dacomitinib		99.74%	是

目录号	产品名	作用方式	纯度	Phase
HY-13427	Allitinib tosylate	Inhibitor	99.83%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-B0793	AZ-5104	Inhibitor	99.91%	否
HY-18609	PD158780	Inhibitor	99.56%	否
HY-P5438	Srctide	Substrate	99.93%	否
HY-168438	ERBB agonist-1		99.16%	否
HY-15375	Allitinib	Inhibitor	99.36%	否
HY-103440	EGFR/ErbB-2/ErbB-4 inhibitor-3	Inhibitor	98.19%	否
HY-112420	EGFR/ErbB-2/ErbB-4 inhibitor-2	Inhibitor	99.45%	否
HY-103441	JNJ28871063 hydrochloride	Inhibitor	98.36%	否
HY-RS04472	ERBB4 Human Pre-designed siRNA Set A		/	否
HY-13272S2	Dacomitinib-d10 dihydrochloride		≥95.0%	否
HY-B0793S1	AZ-5104-d2	Inhibitor	/	否
HY-13272S3	Dacomitinib-d10		/	否
HY-RS04473	Erbb4 Mouse Pre-designed siRNA Set A		/	否
HY-RS04474	Erbb4 Rat Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Erbb4	NCBI	NCBI:2066
Rattus norvegicus	Erbb4	NCBI	NCBI:59323

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